Histone deacetylases (HADC) are the enzymes that remove acetyl group from lysine residue
of histones and non-histone proteins and regulate the process of transcription by binding to …

Acetaminophen (APAP) is a well-known analgesic and antipyretic drug. It is considered to
be safe when administered within its therapeutic range, but in cases of acute intoxication …

Background Sodium phenylbutyrate and taurursodiol have been found to reduce neuronal
death in experimental models. The efficacy and safety of a combination of the two …

Epigenetic mechanisms—including DNA methylation, histone post-translational
modifications and changes in nucleosome positioning—regulate gene expression, cellular …

Alzheimer's disease (AD) is the most common form of dementia in the elderly, and affects
millions of people worldwide. As the number of AD cases continues to increase in both …

Synapses are essential components of neurons and allow information to travel coordinately
throughout the nervous system to adjust behavior to environmental stimuli and to control …

Epigenetics is a quickly growing field encompassing mechanisms regulating gene
expression that do not involve changes in the genotype. Epigenetics is of increasing …

Long-lasting memories require specific gene expression programmes that are, in part,
orchestrated by epigenetic mechanisms. Of the epigenetic modifications identified in …

Alzheimer's disease (AD) is a progressive neurodegenerative disease characterized by
synaptic dysfunction and accumulation of abnormal aggregates formed by amyloid‐β …

An orally administered, fixed‐dose coformulation of sodium phenylbutyrate‐taurursodiol (PB‐
TURSO) significantly slowed functional decline in a randomized, placebo‐controlled, phase …