Tau biomarkers in Alzheimer's disease: towards implementation in clinical practice and trials

R Ossenkoppele, R van der Kant… - The Lancet …, 2022 - thelancet.com
Background Deposition of tau aggregates is a pathological hallmark of Alzheimer's disease
that is closely linked both spatially and temporally to emergence of neurodegeneration and …

Alzheimer's disease: Recent treatment strategies

M Vaz, S Silvestre - European journal of pharmacology, 2020 - Elsevier
Alzheimer Disease (AD) is a neurodegenerative disease characterized by two
neuropathological hallmarks: extracellular deposition of amyloid plaques and intracellular …

Tau-targeting therapies for Alzheimer disease: current status and future directions

EE Congdon, C Ji, AM Tetlow, Y Jiang… - Nature Reviews …, 2023 - nature.com
Alzheimer disease (AD) is the most common cause of dementia in older individuals. AD is
characterized pathologically by amyloid-β (Aβ) plaques and tau neurofibrillary tangles in the …

[HTML][HTML] Current understanding of Alzheimer's disease diagnosis and treatment

J Weller, A Budson - F1000Research, 2018 - ncbi.nlm.nih.gov
Alzheimer's disease is the most common cause of dementia worldwide, with the prevalence
continuing to grow in part because of the aging world population. This neurodegenerative …

Tau and neuroinflammation in Alzheimer's disease: Interplay mechanisms and clinical translation

Y Chen, Y Yu - Journal of neuroinflammation, 2023 - Springer
Alzheimer's Disease (AD) contributes to most cases of dementia. Its prominent
neuropathological features are the extracellular neuritic plaques and intercellular …

Tau-targeting therapies for Alzheimer disease

EE Congdon, EM Sigurdsson - Nature Reviews Neurology, 2018 - nature.com
Alzheimer disease (AD) is the most common form of dementia. Pathologically, AD is
characterized by amyloid plaques and neurofibrillary tangles in the brain, with associated …

Chemically engineered mesoporous silica nanoparticles-based intelligent delivery systems for theranostic applications in multiple cancerous/non-cancerous diseases

S Zhou, Q Zhong, Y Wang, P Hu, W Zhong… - Coordination Chemistry …, 2022 - Elsevier
In recent years, the unprecedented advances of biomedical nanotechnology have spurred
the development of drug delivery systems (DDSs) based on multifarious nanomaterials in …

Alzheimer's disease hypothesis and related therapies

X Du, X Wang, M Geng - Translational neurodegeneration, 2018 - Springer
Alzheimer's disease (AD) is a progressive neurodegenerative disorder and the most
common cause for dementia. There are many hypotheses about AD, including abnormal …

Mesoporous silica and organosilica nanoparticles: physical chemistry, biosafety, delivery strategies, and biomedical applications

JG Croissant, Y Fatieiev, A Almalik… - Advanced healthcare …, 2018 - Wiley Online Library
Predetermining the physico‐chemical properties, biosafety, and stimuli‐responsiveness of
nanomaterials in biological environments is essential for safe and effective biomedical …

Novel therapeutic approaches for Alzheimer's disease: an updated review

TW Yu, HY Lane, CH Lin - International journal of molecular sciences, 2021 - mdpi.com
Alzheimer's disease (AD) is a progressive neurodegenerative disease and accounts for
most cases of dementia. The prevalence of AD has increased in the current rapidly aging …