The detection of pathogens through nucleic acid sensors is a defining principle of innate
immunity. RNA-sensing and DNA-sensing receptors sample subcellular compartments for …

Immune checkpoint inhibitors (ICI) have revolutionised cancer therapy. However, they have
been effective in only a small subset of patients and a principal mechanism underlying …

The stimulator of interferon genes (STING) is an endoplasmic reticulum transmembrane
protein that is a target of therapeutics for infectious diseases and cancer. However, early …

Tumours with an immunosuppressive microenvironment respond poorly to therapy.
Activation of the stimulator of interferon genes (STING) pathway can enhance intratumoural …

Purpose: The stimulator of IFN genes (STING) is a transmembrane protein that plays a role
in the immune response to tumors. Single-agent STING agonist MIW815 (ADU-S100) has …

Cellular recognition of microbial DNA is an evolutionarily conserved mechanism by which
the innate immune system detects pathogens. Cyclic GMP-AMP synthase (cGAS) and its …

Intratumoral (IT) STING activation results in tumor regression in preclinical models, yet
factors dictating the balance between innate and adaptive anti-tumor immunity are unclear …

Notable advances have been achieved in the treatment of cancer since the advent of
immunotherapy, and immune checkpoint inhibitors have shown clinical benefit across a …

During tumor progression, a subset of cancer cells escape from immune surveillance and
eventually develop into measurable tumor mass. Cancer immunotherapy eradicates tumor …

Abstract Purpose: Natural killer (NK)-cell–based immunotherapy may overcome obstacles to
effective T-cell–based immunotherapy such as the presence of genomic alterations in IFN …