Novel metals and metal complexes as platforms for cancer therapy

M Frezza, S Hindo, D Chen… - Current …, 2010 - ingentaconnect.com
Metals are essential cellular components selected by nature to function in several
indispensable biochemical processes for living organisms. Metals are endowed with unique …

Zinc metabolism in the brain: relevance to human neurodegenerative disorders

MP Cuajungco, GJ Lees - Neurobiology of disease, 1997 - Elsevier
Zinc is an important trace element in biology. An important pool of zinc in the brain is the one
present in synaptic vesicles in a subgroup of glutamatergic neurons. In this form it can be …

The important role of the apoptotic effects of zinc in the development of cancers

RB Franklin, LC Costello - Journal of cellular biochemistry, 2009 - Wiley Online Library
Zinc is a trace element that is essential for the normal function of cells. It is a cofactor for the
structure and function of a wide range of cellular proteins including enzymes, transcription …

Consequences of trace metal variability and supplementation on Chinese hamster ovary (CHO) cell culture performance: A review of key mechanisms and …

RJ Graham, H Bhatia, S Yoon - Biotechnology and …, 2019 - Wiley Online Library
Trace metals are supplied to chemically‐defined media (CDM) for optimal Chinese hamster
ovary (CHO) cell culture performance during the production of monoclonal antibodies and …

Mitochondrial function, zinc, and intermediary metabolism relationships in normal prostate and prostate cancer

LC Costello, RB Franklin, P Feng - Mitochondrion, 2005 - Elsevier
Human prostate secretory epithelial cells have the uniquely specialized function of
accumulating and secreting extremely high levels of citrate. This is achieved by their ability …

[HTML][HTML] Zinc: Multidimensional effects on living organisms

MP Cuajungco, MS Ramirez, ME Tolmasky - Biomedicines, 2021 - mdpi.com
Zinc is a redox-inert trace element that is second only to iron in abundance in biological
systems. In cells, zinc is typically buffered and bound to metalloproteins, but it may also exist …

Role of free radicals and metal ions in the pathogenesis of Alzheimer's disease

CS Atwood, X Huang, RD Moir, RE Tanzi… - Metal ions in biological …, 2018 - taylorfrancis.com
This chapter reviews transition metal ion dysregulation and oxidative stress in the
pathogenesis of Alzheimer's disease. It focuses on the roles of metal ions in …

Dithiocarbamate-based coordination compounds as potent proteasome inhibitors in human cancer cells

D Buac, S Schmitt, G Ventro… - Mini reviews in …, 2012 - ingentaconnect.com
Dithiocarbamates are a class of metal-chelating compounds with various applications in
medicine. They have been used for the treatment of bacterial and fungal infections, possible …

Direct effect of zinc on mitochondrial apoptogenesis in prostate cells

P Feng, TL Li, ZX Guan, RB Franklin… - The Prostate, 2002 - Wiley Online Library
BACKGROUND Prostate epithelial cells uniquely accumulate significantly higher levels of
zinc than other mammalian cells. We previously showed that the accumulation of high …

[HTML][HTML] Zinc and zinc transporters in normal prostate function and the pathogenesis of prostate cancer

RB Franklin, B Milon, P Feng… - Frontiers in bioscience: a …, 2005 - ncbi.nlm.nih.gov
Zinc is an essential metal for all cells. It plays a role in a wide variety of physiological and
biochemical processes. In the prostate epithelial cell the accumulation of high cellular zinc is …