Type I collagen is the most abundant structural protein in vertebrates. It is a heterotrimeric
molecule composed of two α1 chains and one α2 chain, forming a long uninterrupted triple …

Collagen is the major component of extracellular matrix. Collagen cross-link and deposition
depend on lysyl hydroxylation, which is catalyzed by procollagen-lysine, 2-oxoglutarate 5 …

Heterotrimers composed of collagen type IV alpha 1 (COL4A1) and alpha 2 (COL4A2)
constitute one of the most abundant components of nearly all basement membranes …

Intratumoral hypoxia and expression of hypoxia-inducible factor-1α (HIF-1α) correlate with
metastasis and poor survival in patients with sarcoma. We show here that hypoxia controls …

The collagen VI-related myopathy known as Ullrich congenital muscular dystrophy is an
early-onset disease that combines substantial muscle weakness with striking joint laxity and …

Collagen is a macromolecule that has versatile roles in physiology, ranging from structural
support to mediating cell signaling. Formation of mature collagen fibrils out of procollagen α …

Wound healing is one of the most complex processes in multicellular organisms, involving
numerous intra-and intercellular signalling pathways in various cell types. It involves …

Collagens are the most abundant proteins in the extracellular matrix. They provide a
framework to build organs and tissues and give structural support to make them resistant to …

The most abundant protein found in mammals is collagen, and there are around 28 different
types of collagen found in the human body, but there are five types, namely, Type I, Type II …

Basement membranes (BMs) are specialized extracellular matrices that are essential for
epithelial structure and morphogenesis. However, little is known about how BM proteins are …