The term “click chemistry” describes a class of organic transformations that were developed
to make chemical synthesis simpler and easier, in essence allowing chemists to combine …

Bioorthogonal chemistry involves selective biocompatible reactions between functional
groups that are not normally present in biology. It has been used to probe biomolecules in …

Due to their high reaction rate and reliable selectivity, bioorthogonal click reactions have
been extensively investigated in numerous research fields, such as nanotechnology, drug …

Star polymers are structures composed of multiple functional linear arms covalently
connected through a central core. The unique conformation of star polymers, with their …

Soft polymer nanoparticles designed to disassemble and release an antagonist of the
neurokinin 1 receptor (NK 1 R) in endosomes provide efficacious yet transient relief from …

Bioorthogonal chemistry comprises chemical reactions that can take place inside complex
biological environments, providing outstanding tools for the investigation and elucidation of …

Nanomedicine is revolutionizing the treatment of cancer and has achieved unprecedented
outcomes over the past decades. The accumulation of Nanoparticles (NPs) in different …

Over the past decades, the pretargeted strategy has emerged as a promising approach to
improve delivery of nucleotides into tumor tissues for nuclear imaging and/or therapy. Unlike …

The premature leakage of chemotherapeutics during delivery impedes drugs from entering
tumor cells, which produces considerable side effects in normal organs. Herein, we describe …

Abstract Purpose Nanodiamonds (NDs) represent a new class of nanoparticles and have
gained increasing interest in medical applications. Modifying the surface coating by …