Capping protein regulators fine-tune actin assembly dynamics

M Edwards, A Zwolak, DA Schafer, D Sept… - … reviews Molecular cell …, 2014 - nature.com
Capping protein (CP) binds the fast growing barbed end of the actin filament and regulates
actin assembly by blocking the addition and loss of actin subunits. Recent studies provide …

Regulation of the actin cytoskeleton-plasma membrane interplay by phosphoinositides

J Saarikangas, H Zhao… - Physiological …, 2010 - journals.physiology.org
The plasma membrane and the underlying cortical actin cytoskeleton undergo continuous
dynamic interplay that is responsible for many essential aspects of cell physiology …

New insights into mechanism and regulation of actin capping protein

JA Cooper, D Sept - International review of cell and molecular biology, 2008 - Elsevier
The heterodimeric actin capping protein, referred to here as “CP,” is an essential element of
the actin cytoskeleton, binding to the barbed ends of actin filaments and regulating their …

Critical shifts in lipid metabolism promote megakaryocyte differentiation and proplatelet formation

B de Jonckheere, F Kollotzek, P Münzer… - Nature cardiovascular …, 2023 - nature.com
During megakaryopoiesis, megakaryocytes (MKs) undergo cellular morphological changes
with strong modification of membrane composition and lipid signaling. Here, we adopt a lipid …

Structural characterization of a capping protein interaction motif defines a family of actin filament regulators

M Hernandez-Valladares, T Kim, B Kannan… - Nature structural & …, 2010 - nature.com
Capping protein (CP) regulates actin dynamics by binding the barbed ends of actin
filaments. Removal of CP may be one means to harness actin polymerization for processes …

Polydatin promotes Nrf2-ARE anti-oxidative pathway through activating CKIP-1 to resist HG-induced up-regulation of FN and ICAM-1 in GMCs and diabetic mice …

W Gong, J Li, Z Chen, J Huang, Q Chen, W Cai… - Free Radical Biology …, 2017 - Elsevier
Our previous study indicated that Casein kinase 2 interacting protein-1 (CKIP-1) could
promote the activation of the nuclear factor E2-related factor 2 (Nrf2)/antioxidant response …

CKIP-1 inhibits cardiac hypertrophy by regulating class II histone deacetylase phosphorylation through recruiting PP2A

S Ling, Q Sun, Y Li, L Zhang, P Zhang, X Wang… - Circulation, 2012 - Am Heart Assoc
Background—Sustained cardiac pressure overload–induced hypertrophy and pathological
remodeling frequently leads to heart failure. Casein kinase-2 interacting protein-1 (CKIP-1) …

Heterodimeric capping protein is required for stereocilia length and width regulation

MR Avenarius, JF Krey, RA Dumont, CP Morgan… - Journal of Cell …, 2017 - rupress.org
Control of the dimensions of actin-rich processes like filopodia, lamellipodia, microvilli, and
stereocilia requires the coordinated activity of many proteins. Each of these actin structures …

CKIP-1 limits foam cell formation and inhibits atherosclerosis by promoting degradation of Oct-1 by REGγ

J Fan, L Liu, Q Liu, Y Cui, B Yao, M Zhang… - Nature …, 2019 - nature.com
Atherosclerosis-related cardiovascular diseases are the leading cause of mortality
worldwide. Macrophages uptake modified lipoproteins and transform into foam cells …

Two distinct mechanisms for actin capping protein regulation—steric and allosteric inhibition

S Takeda, S Minakata, R Koike, I Kawahata… - PLoS …, 2010 - journals.plos.org
The actin capping protein (CP) tightly binds to the barbed end of actin filaments, thus playing
a key role in actin-based lamellipodial dynamics. V-1 and CARMIL proteins directly bind to …