Disorders of cell number that result from an imbalance between the death of parenchymal
cells and the proliferation or recruitment of maladaptive cells contributes to the pathogenesis …

Inflammasomes are large cytosolic multiprotein complexes assembled in response to
infection and cellular stress, and are crucial for the activation of inflammatory caspases and …

Sepsis is defined as life-threatening organ dysfunction caused by a dysregulated host
response to infection. Recently was been found that pyroptosis is a unique form of …

Pyroptosis, one kind of inflammatory regulated cell death, is involved in various inflammatory
diseases, including acute kidney injury (AKI). Besides Gasdermin D (GSDMD), GSDME is a …

Sepsis is defined as organ dysfunction due to a dysregulated systemic host response to
infection. During gram-negative bacterial infection and other acute illness such as …

Acute kidney injury (AKI) is a worldwide problem, and there is no effective drug to eliminate
AKI. The death of renal cells is an important pathological basis of intrinsic AKI. At present …

Sepsis-associated acute kidney injury (SA-AKI) is common in patients with severe sepsis,
and has a high incidence rate and high mortality rate in ICU patients. Most patients progress …

Myocardial dysfunction is a serious consequence of sepsis and contributes to high mortality.
Currently, the molecular mechanism of myocardial dysfunction induced by sepsis remains …

The nod-like receptor protein-3 (NLRP3)-mediated pyroptosis is involved in kidney
diseases. Thioredoxin interacting protein (TXNIP) directly interacts with NLRP3. This study …

Sepsis has evolved as an enormous health issue amongst critically ill patients. It is a major
risk factor that results in multiple organ failure and shock. Acute kidney injury (AKI) is one of …