Metabolic reprogramming is involved in the pathogenesis of not only cancers but also
neurodegenerative diseases, cardiovascular diseases, and infectious diseases. With the …

Protein lipidation, including cysteine prenylation, N-terminal glycine myristoylation, cysteine
palmitoylation, and serine and lysine fatty acylation, occurs in many proteins in eukaryotic …

Protein lipid modification involves the attachment of hydrophobic groups to proteins via
ester, thioester, amide, or thioether linkages. In this review, the specific click chemical …

The lipid post‐translational modification S‐palmitoylation is a vast developing field, with the
modification itself and the enzymes that catalyse the reversible reaction implicated in a …

Post-translational attachment of lipids to proteins is found in all organisms, and is important
for many biological processes. Acylation with myristic and palmitic acids are among the most …

S-Palmitoylation is the only reversible post-translational lipid modification. Knowledge about
the DHHC palmitoyltransferase family is still limited. Here we show that human ZDHHC6 …

Blood-testis barrier (BTB) damage promotes spermatogenesis dysfunction, which is a critical
cause of male infertility. Dyslipidemia has been correlated with male infertility, but the major …

Protein palmitoylation plays diverse roles in regulating the trafficking, stability, and activity of
cellular proteins. The advent of click chemistry has propelled the field of protein …

Mammalian voltage-activated L-type Ca2+ channels, such as Ca (v) 1.2, control
transmembrane Ca2+ fluxes in numerous excitable tissues. Here, we report that the pore …

Protein S-acylation is the reversible addition of fatty acids to the cysteine residues of target
proteins. It regulates multiple aspects of protein function, including the localization to …