Depression and its phytopharmacotherapy—a narrative review

L Dobrek, K Głowacka - International Journal of Molecular Sciences, 2023 - mdpi.com
Depression is a mental health disorder that develops as a result of complex psycho-neuro-
immuno-endocrinological disturbances. This disease presents with mood disturbances …

[HTML][HTML] A qualitative and quantitative comparison of Crocus sativus and Nigella sativa immunomodulatory effects

MR Khazdair, Z Gholamnezhad, R Rezaee… - Biomedicine & …, 2021 - Elsevier
The present article reviews and compares the immunomodulatory activities of Crocus
sativus (C. sativus) and Nigella sativa (N. sativa) and their main bioactive compounds …

Amelioration of anxiety, depression, and chemotherapy related toxicity after crocin administration during chemotherapy of breast cancer: a double blind, randomized …

R Salek, M Dehghani, SA Mohajeri… - Phytotherapy …, 2021 - Wiley Online Library
The effects of saffron (Crocus sativus L.) on mood disorders have already been established.
More recently, its anti‐neoplastic effects have provoked a great attention. This study aims to …

The molecular basis of the immunomodulatory effects of natural products: a comprehensive review

S Beigoli, MH Boskabady - Phytomedicine, 2024 - Elsevier
Abstract Background Natural products (NPs) have long been recognized for their potential to
modulate the immune system, offering a natural and holistic approach to enhancing immune …

[HTML][HTML] Saffron as a Promising Therapy for Inflammatory Bowel Disease

M Rashid, R Rashid, S Saroya, M Deverapalli, H Brim… - Nutrients, 2024 - mdpi.com
Inflammatory bowel disease (IBD) is a chronic inflammatory illness of the gastrointestinal
tract (GI), characterized by recurrent episodes of inflammation and tissue destruction. It …

[HTML][HTML] Critical review and Mechanistic insights into the health-protective and Immunomodulatory activity of Tiryāq (Theriac) from the purview of Unani medicine

S Nikhat, M Fazil - Brain Behavior and Immunity Integrative, 2023 - Elsevier
Background The theriac, known in Arabic as tiryāq, is a medicinal panacea and an
alexipharmic which was conceptualized during the 2 nd century BC. During medieval ages …

Leu27IGF‐II‐induced hypertrophy in H9c2 cardiomyoblasts is ameliorated by saffron by regulation of calcineurin/NFAT and CaMKIIδ signaling

CY Lin, MA Shibu, R Wen, CH Day… - Environmental …, 2021 - Wiley Online Library
The insulin‐like growth factor II receptor (IGF‐IIR) induces myocardial hypertrophy under
various pathological conditions like diabetes and hypertension via G protein receptors like …

Crocus sativus L. Extract (Saffron) Effectively Reduces Arthritic and Inflammatory Parameters in Monotherapy and in Combination with Methotrexate in Adjuvant …

M Chrastina, F Dráfi, K Pružinská, S Poništ, KS Kamga… - Nutrients, 2023 - mdpi.com
Rheumatoid arthritis (RA), an autoimmune disease, is characterized by inflammation that
affects not only the liver but also other organs and the musculoskeletal system. The standard …

Stimulating effect of nanocurcumin and crocin on proliferation and pluripotency of bone marrow-derived mesenchymal stem cells

N Sabouni, M Mohammadi… - Iranian Journal of …, 2024 - pmc.ncbi.nlm.nih.gov
Objective (s): Enhancement of proliferation, pluripotency, and self-renewal capacity as the
unique features of MSCs can improve their therapeutic potential to regenerate tissues. In this …

New monoterpenoids from the stigmas of Crocus sativus

QW Fang, WW Fu, JL Yang, Y Lu, JC Chen… - Journal of natural …, 2022 - Springer
One new compound, crocusatin M (1), and three new glycosidic compounds, crocusatins NP
(2–4), along with nine known compounds were isolated from the dried stigmas of Crocus …