Prostanoids are the cyclooxygenase metabolites of arachidonic acid and include
prostaglandin (PG) D2, PGE2, PGF2α, PGI2, and thromboxne A2. They are synthesized and …

Publisher Summary This chapter focuses on interleukin-8 (IL-8) and related chemotactic
cytokines—namely, CXC and CC chemokines. IL-8 is the best known member of a new …

Abstract The Concise Guide to PHARMACOLOGY 2013/14 provides concise overviews of
the key properties of over 2000 human drug targets with their pharmacology, plus links to an …

▪ Abstract Platelet-activating factor (PAF) is a phospholipid with potent, diverse physiological
actions, particularly as a mediator of inflammation. The synthesis, transport, and degradation …

Lysophosphatidic acid (LPA) is a bioactive lipid mediator with diverse physiological and
pathological actions on many types of cells. LPA has been widely considered to elicit its …

Several chemotactic agonists including interleukin-8 (IL-8) and related cytokines have been
shown to activate and attract leukocytes via seven-transmembrane domain, GTP-binding …

Platelet-activating factor (PAF) is a phospholipid mediator that belongs to a family of
biologically active, structurally related alkyl phosphoglycerides. PAF acts via a specific …

Platelet-activating factor (PAF, 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine) is a
biologically active phospholipid mediator. Although PAF was initially recognized for its …

During the past two decades, studies describing the chemistry and biology of PAF have
been extensive. This potent phosphoacylglycerol exhibits a wide variety of physiological and …

Adult respiratory distress syndrome (ARDS) is characterized by acute lung injury with a high
mortality rate and yet its mechanism is poorly understood. Sepsis syndrome and acid …