Micro‐inflammation in functional dyspepsia: a systematic review and meta‐analysis

L Du, B Chen, JJ Kim, X Chen… - Neurogastroenterology & …, 2018 - Wiley Online Library
Abstract Background and Purpose Functional dyspepsia (FD) is a gastrointestinal disorder
of unknown etiology. Although micro‐inflammation appears to be important in the …

The role of leaky gut in functional dyspepsia

L Wauters, M Ceulemans, J Schol, R Farré… - Frontiers in …, 2022 - frontiersin.org
Patients with functional dyspepsia (FD) complain of epigastric symptoms with no identifiable
cause. Increased intestinal permeability has been described in these patients, especially in …

IgE-mediated mast cell activation promotes inflammation and cartilage destruction in osteoarthritis

Q Wang, CM Lepus, H Raghu, LL Reber, MM Tsai… - Elife, 2019 - elifesciences.org
Osteoarthritis is characterized by articular cartilage breakdown, and emerging evidence
suggests that dysregulated innate immunity is likely involved. Here, we performed …

Increased duodenal eosinophil degranulation in patients with functional dyspepsia: a prospective study

L Du, J Shen, JJ Kim, Y Yu, L Ma, N Dai - Scientific reports, 2016 - nature.com
Functional dyspepsia (FD) is a functional gastrointestinal disorder diagnosed by symptom-
based criteria. It has been said that duodenal immune activation plays a role in the …

A role for mast cells and mast cell tryptase in driving neutrophil recruitment in LPS-induced lung inflammation via protease-activated receptor 2 in mice

AD de Almeida, IS Silva, W Fernandes-Braga… - Inflammation …, 2020 - Springer
Objective This study aims to investigate the role of protease-activated receptor (PAR) 2 and
mast cell (MC) tryptase in LPS-induced lung inflammation and neutrophil recruitment in the …

Anti-asthma potential of crocin and its effect on MAPK signaling pathway in a murine model of allergic airway disease

Y Xiong, J Wang, H Yu, X Zhang… - Immunopharmacology …, 2015 - Taylor & Francis
Context: Crocin, a diterpenoid glucoside, has multitudinous activities such as anti-
inflammation, anti-allergy, anti-oxidation and relaxing smooth muscles. Objective: In this …

Hepatic ischemia/reperfusion injury involves functional tryptase/PAR-2 signaling in liver sinusoidal endothelial cell population

J Song, Z He, M Yang, T Yu, X Wang, B Liu… - International …, 2021 - Elsevier
Mast cells (MCs) are tissue-resident effector cells that could be the earliest responder to
release a unique, stimulus-specific set of mediators in hepatic ischemia–reperfusion (IR) …

Immunopathological and molecular basis of functional dyspepsia and current therapeutic approaches

M Addula, VED Wilson, S Reddymasu… - Expert review of …, 2018 - Taylor & Francis
Introduction: Functional dyspepsia (FD) is widespread with 20% prevalence worldwide and
a significant economic burden due to health care cost and constraints on daily activities of …

Biomarkers and their possible functions in the intestinal microenvironment of chagasic megacolon: an overview of the (neuro) inflammatory process

JR do Carmo Neto, YLL Braga… - Journal of …, 2021 - Wiley Online Library
The association between inflammatory processes and intestinal neuronal destruction during
the progression of Chagasic megacolon is well established. However, many other …

Induction of mast cell accumulation by tryptase via a protease activated receptor‐2 and ICAM‐1 dependent mechanism

X Liu, J Wang, H Zhang, M Zhan, H Chen… - Mediators of …, 2016 - Wiley Online Library
Mast cells are primary effector cells of allergy, and recruitment of mast cells in involved
tissue is one of the key events in allergic inflammation. Tryptase is the most abundant …