Endogenous glucocorticoids are crucial to various physiological processes, including
metabolism, development and inflammation. Since 1948, synthetic glucocorticoids have …

Platelets are small anucleate blood cells generated from megakaryocytes in the bone
marrow and cleared in the reticuloendothelial system. At the site of vascular injury, platelet …

Immune thrombocytopenia (ITP) is an autoimmune disease defined by low platelet counts
which presents with an increased bleeding risk. Several genetic risk factors (eg …

Platelets, small anucleate cells circulating in the blood, are critical mediators in haemostasis
and thrombosis. Interestingly, recent studies demonstrated that platelets contain both pro …

Recent evidence of distinct ITP pathophysiology has opened new exploratory avenues for
disease management. We will discuss the utility of investigations into these mechanisms of …

Platelets are small, versatile blood cells that are critical for hemostasis/thrombosis. Local
platelet accumulation is a known contributor to proinflammation in various disease states …

Lower-than-normal platelet counts are a hallmark of the acquired autoimmune illness known
as immune thrombocytopenia, which can affect both adults and children. Immune …

The clinical success of dendritic cell (DC)-based genetic immunization remains critically
dependent on the availability of effective and safe nano-carriers for targeting antigen …

Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of immature
cells and natural inhibitors of adaptive immunity. Intracellular metabolic changes in MDSCs …

Thrombopoietin (TPO), a hematopoietic growth factor produced predominantly by the liver, is
essential for thrombopoiesis. Prevailing theory posits that circulating TPO levels are …