Quinolines and structurally related heterocycles as antimalarials
The quinoline scaffold is prevalent in a variety of pharmacologically active synthetic and
natural compounds. The discovery of chloroquine, the most famous drug containing this …
natural compounds. The discovery of chloroquine, the most famous drug containing this …
Primaquine revisited six decades after its discovery
Primaquine was firstly synthesized in 1946 in the USA, and is the most representative
member of the anti-malarial 8-aminoquinolines. Six decades have passed and primaquine …
member of the anti-malarial 8-aminoquinolines. Six decades have passed and primaquine …
Antioxidant, antimalarial and antimicrobial activities of tannin-rich fractions, ellagitannins and phenolic acids from Punica granatum L.
MK Reddy, SK Gupta, MR Jacob, SI Khan… - Planta …, 2007 - thieme-connect.com
The Punica granatum L.(pomegranate) by-product POMx was partitioned between water,
EtOAc and n-BuOH, and the EtOAc and n-BuOH extracts were purified by XAD-16 and …
EtOAc and n-BuOH, and the EtOAc and n-BuOH extracts were purified by XAD-16 and …
Quinoline-based antifungals
Although the assortment of antifungal drugs is broad, the most commonly used agents have
major drawbacks. Toxicity, serious side effects or the emergence of drug resistance are …
major drawbacks. Toxicity, serious side effects or the emergence of drug resistance are …
Advances in the syntheses of quinoline and quinoline-annulated ring systems
S Madapa, Z Tusi, S Batra - Current Organic Chemistry, 2008 - ingentaconnect.com
Quinoline is a heterocyclic scaffold of paramount importance to human race. The utility of
quinoline derivatives in the areas of medicine, food, catalyst, dye, materials, refineries and …
quinoline derivatives in the areas of medicine, food, catalyst, dye, materials, refineries and …
Fruitful decade for antileishmanial compounds from 2002 to late 2011
Leishmaniasis, usually caused by the genus Leishmania, has not received the attention it
deserves and in recent times has developed into a major health problem worldwide. 1, 2 …
deserves and in recent times has developed into a major health problem worldwide. 1, 2 …
Novel 4-aminoquinoline-pyrimidine based hybrids with improved in vitro and in vivo antimalarial activity
A class of hybrid molecules consisting of 4-aminoquinoline and pyrimidine were synthesized
and tested for antimalarial activity against both chloroquine (CQ)-sensitive (D6) and …
and tested for antimalarial activity against both chloroquine (CQ)-sensitive (D6) and …
Recent developments in the design and synthesis of hybrid molecules basedon aminoquinoline ring and their antiplasmodial evaluation
VV Kouznetsov, A Gómez-Barrio - European journal of medicinal chemistry, 2009 - Elsevier
A short history of hybrid molecules based on aminoquinolines gave interesting and
important information useful for organic and medicinal chemistry, which are deeply involved …
important information useful for organic and medicinal chemistry, which are deeply involved …
Structural modifications of quinoline-based antimalarial agents: Recent developments
Antimalarial drugs constitute a major part of antiprotozoal drugs and have been in practice
for a long time. Antimalarial agents generally belong to the class of quinoline which acts by …
for a long time. Antimalarial agents generally belong to the class of quinoline which acts by …
Hydrazones of 2-aryl-quinoline-4-carboxylic acid hydrazides: Synthesis and preliminary evaluation as antimicrobial agents
KA Metwally, LM Abdel-Aziz, ESM Lashine… - Bioorganic & medicinal …, 2006 - Elsevier
A new series of 2-arylquinoline-4-carboxylic acid hydrazide–hydrazones was synthesized
using an appropriate synthetic route. All the target compounds were evaluated for their in …
using an appropriate synthetic route. All the target compounds were evaluated for their in …