In recent years, accumulating evidence has elucidated the role of lysosomes in dynamically
regulating cellular and organismal homeostasis. Lysosomal changes and dysfunction have …

The pH in tumour cells and the tumour microenvironment has played important roles in
cancer development and treatment. It was thought that both the extracellular and …

The high metabolic rate of tumours often leads to acidosis and hypoxia in poorly perfused
regions. Tumour cells have thus evolved the ability to function in a more acidic environment …

Cells maintain intracellular pH (pHi) within a narrow range (7.1–7.2) by controlling
membrane proton pumps and transporters whose activity is set by intra-cytoplasmic pH …

Transmembrane ATPases are membrane-bound enzyme complexes and ion transporters
that can be divided into F-, V-, and A-ATPases according to their structure. The V-ATPases …

Covering: 2011–July 2016 Myxobacteria are a rich source for structurally diverse secondary
metabolites with intriguing biological activities. Here we report on new natural products that …

Cancer is a metabolic disease and the solution of two metabolic equations: to produce
energy with limited resources and to fulfill the biosynthetic needs of proliferating cells. Both …

A distinguishing phenotype of solid tumors is the presence of an alkaline cellular feature
despite the surrounding acidic microenvironment. This phenotypic characteristic of tumors …

Rapidly dividing and invasive cancer cells are strongly dependent on effective lysosomal
function. Accordingly, transformation and cancer progression are characterized by dramatic …

During tumor progression, lysosome function is often maladaptively upregulated to match
the high energy demand required for cancer cell hyper-proliferation and invasion. Here, we …