Background: Statins have long been used for the protection against coronary artery disease
(CAD). Their beneficial effect apart from cholesterol reduction lies in their pleiotropic …

The cholesterol biosynthesis pathway, also known as the mevalonate (MVA) pathway, is an
essential cellular pathway that is involved in diverse cell functions. The enzyme 3-hydroxy-3 …

Background Statins and aspirin have been proposed for treatment of COVID-19 because of
their anti-inflammatory and anti-thrombotic properties. Several observational studies have …

Background aims Stem cells may be a promising therapy for acute respiratory distress
syndrome. Recent in vivo and in vitro studies suggested that the mesenchymal stromal cells …

Cardiovascular diseases, which are the leading cause of mortality in the Western World, are
closely associated with atherosclerosis development. Atherosclerosis is a chronic …

Alveolar-capillary leak is a hallmark of the acute respiratory distress syndrome (ARDS), a
potentially lethal complication of severe sepsis, trauma and pneumonia, including COVID …

Curcumin has potent antioxidant and anti-inflammatory properties but poor absorption
following oral administration owing to its low aqueous solubility. Development of novel …

Disruption of the alveolar–endothelial barrier caused by inflammation leads to the
progression of septic acute lung injury (ALI). In the present study, we investigated the …

Hydroxysafflor yellow A (HSYA) is a main bio-active compound important of a traditional
Chinese medicine named Carthamus tinctorius L. and has been shown to possess various …

Critically ill patients with sepsis require a multidisciplinary approach, as this situation implies
multiorgan distress, with most of the bodily biochemical and cellular systems being affected …