With the application of high throughput sequencing technologies at single-cell resolution,
studies of the tumor microenvironment in glioblastoma, one of the most aggressive and …

Diabetes is one of the most comprehensive metabolic disorders and is spread across the
globe. The data from IDF Diabetes Atlas and National Diabetes Statistics mentions that the …

Alkylation at the O6 position of guanine is a common and highly mutagenic form of DNA
damage. Direct repair of O6-alkylguanines by the “suicide” enzyme O6-methylguanine DNA …

Despite the known influence of DNA methylation from lipopolysaccharide (LPS) activation,
data on the O6-methylguanine-DNA methyltransferase (MGMT, a DNA suicide repair …

Lower-grade gliomas (LGGs) are slow-growing, indolent tumors that usually affect younger
patients and present a therapeutic challenge due to the heterogeneity of their clinical …

Aging increases the risks for developing fibrocontractile membranes on the retina, which
causes significant macular distortion, as in the idiopathic epiretinal membrane (iERM) …

Purpose Glioma is the most common and fatal type of brain tumour. Owing to its
aggressiveness and lethality, early diagnosis and prediction of patient survival are very …

The O6-methylguanine-DNA methyltransferase (MGMT) is a DNA suicide repair enzyme that
might be important during sepsis but has never been explored. Then, the proteomic analysis …

Background and purpose Activation of some signaling pathways can promote cell survival
and have a negative impact on tumor response to radiotherapy. Here, the role of differences …

Background Despite rapid developments in immunotherapy and targeted therapy,
dacarbazine (DTIC)-based chemotherapy still has been placed at the first-line for advanced …