In 1929 Drury and Szent-Györgyi published a seminal paper describing the potent actions of
adenine compounds. Some decades later, adenosine 5'-triphosphate (ATP) was proposed …

P2 membrane receptors are specifically activated by extracellular nucleotides like ATP,
ADP, UTP, and UDP. P2 receptors are subdivided into metabotropic P2Y and ionotropic P2X …

All cells release nucleotides and are in one way or another involved in local autocrine and
paracrine regulation of organ function via stimulation of purinergic receptors. Significant …

The prevalence of hypertension in African Americans (AAs) is higher than in other US
groups; yet, few have performed genome-wide association studies (GWASs) in AA. Among …

The understanding of the nucleotide/P2 receptor system in the regulation of renal
hemodynamics and transport function has grown exponentially over the last 20 yr. This …

The aldosterone-sensitive distal nephron (ASDN) includes the late distal convoluted tubule
2, the connecting tubule (CNT) and the collecting duct. The appropriate regulation of sodium …

Nucleotides are key subunits for nucleic acids and provide energy for intracellular
metabolism. They can also be released from cells to act physiologically as extracellular …

Extracellular nucleotides (eg, ATP) regulate many physiological and pathophysiological pro‐
cesses through activation of nucleotide (P2) receptors in the plasma membrane. Here we …

Inactivation of the B1 proton pump subunit (ATP6V1B1) in intercalated cells (ICs) leads to
type I distal renal tubular acidosis (dRTA), a disease associated with salt-and potassium …

Using patch clamp techniques, we found that the epithelial sodium channel (ENaC) activity
in the apical membrane of A6 distal nephron cells showed a sudden rundown beginning at 4 …