Cancer progression with uncontrolled tumor growth, local invasion, and metastasis depends
largely on the proteolytic activity of numerous matrix metalloproteinases (MMPs), which …

Podosomes and invadopodia are actin-based dynamic protrusions of the plasma membrane
of metazoan cells that represent sites of attachment to—and degradation of—the …

Tumor-derived exosomes and their contents promote cancer metastasis. Phosphoglycerate
mutase 1 (PGAM1) is involved in various cancer-related processes. Nevertheless, the …

Cell migration is fundamental to establishing and maintaining the proper organization of
multicellular organisms. Morphogenesis can be viewed as a consequence, in part, of cell …

Cell-directed changes in the ligand-binding affinity ('activation') of integrins regulate cell
adhesion and migration, extracellular matrix assembly and mechanotransduction, thereby …

The metastatic process, ie the dissemination of cancer cells throughout the body to seed
secondary tumors at distant sites, requires cancer cells to leave the primary tumor and to …

The fusion of myoblasts into multinucleate syncytia plays a fundamental role in muscle
function, as it supports the formation of extended sarcomeric arrays, or myofibrils, within a …

The basement membrane is a thin but dense, sheet-like specialized type of extracellular
matrix that has remarkably diverse functions tailored to individual tissues and organs. Tightly …

Cell adhesions mediate important bidirectional interactions between cells and the
extracellular matrix. They provide an interactive interface between the extracellular chemical …

Polymerization of actin filaments directed by the actin-related protein (Arp) 2/3 complex
supports many types of cellular movements. However, questions remain regarding the …