Pili are crucial virulence factors for many Gram-negative pathogens. These surface
structures provide bacteria with a link to their external environments by enabling them to …

Bladder infections affect millions of people yearly, and recurrent symptomatic infections
(cystitis) are very common. The rapid increase in infections caused by multidrug-resistant …

Urinary tract infections (UTI) are one of the most common bacterial infections, with roughly
eleven‐million cases reported in the US each year that cost an estimated $5 billion annually …

This is the second edition of our little red book Lectins published in 1989. In the intervening
years well over 10,000 articles have appeared with lectins as the main subject, and more …

The first step in the colonization of the human urinary tract by pathogenic Escherichia coli is
the mannose‐sensitive binding of FimH, the adhesin present at the tip of type 1 pili, to the …

The chaperone–usher (CU) pathway of pilus biogenesis is the most widespread of the five
pathways that assemble adhesive pili at the surface of Gram-negative bacteria. Recent …

Pseudomonas aeruginosa, an important opportunistic human pathogen, persists in certain
tissues in the form of specialized bacterial communities, referred to as biofilm. The biofilm is …

Many Proteobacteria use the chaperone/usher pathway to assemble proteinaceous
filaments on the bacterial surface. These filaments can curl into fimbrial or nonfimbrial …

A chemical synthesis platform with broad applications and flexibility was rationally designed
to inhibit biogenesis of adhesive pili assembled by the chaperone–usher pathway in Gram …

Vibrio cholerae is a bacterial pathogen that colonizes the chitinous exoskeleton of
zooplankton as well as the human gastrointestinal tract. Colonization of these different …