Pharmacology of heparin and related drugs: an update

J Hogwood, B Mulloy, R Lever, E Gray, CP Page… - Pharmacological …, 2023 - Elsevier
Heparin has been used extensively as an antithrombotic and anticoagulant for close to 100
years. This anticoagulant activity is attributed mainly to the pentasaccharide sequence …

Effects of neurological disorders on bone health

RR Kelly, SJ Sidles, AC LaRue - Frontiers in psychology, 2020 - frontiersin.org
Neurological diseases, particularly in the context of aging, have serious impacts on quality of
life and can negatively affect bone health. The brain-bone axis is critically important for …

The contact activation inhibitor AB023 in heparin-free hemodialysis: results of a randomized phase 2 clinical trial

CU Lorentz, EI Tucker, NG Verbout… - Blood, The Journal …, 2021 - ashpublications.org
End-stage renal disease (ESRD) patients on chronic hemodialysis have repeated blood
exposure to artificial surfaces that can trigger clot formation within the hemodialysis circuit …

The use of the anticoagulant heparin and corticosteroid dexamethasone as prominent treatments for COVID-19

HA Braz-de-Melo, SS Faria… - Frontiers in …, 2021 - frontiersin.org
COVID-19 is spreading worldwide at disturbing rates, overwhelming global healthcare.
Mounting death cases due to disease complications highlight the necessity of describing …

Secondary osteoporosis and metabolic bone diseases

MM Sobh, M Abdalbary, S Elnagar, E Nagy… - Journal of Clinical …, 2022 - mdpi.com
Fragility fracture is a worldwide problem and a main cause of disability and impaired quality
of life. It is primarily caused by osteoporosis, characterized by impaired bone quantity and or …

Anticoagulation in hemodialysis: a narrative review

SE Claudel, LA Miles, M Murea - Seminars in Dialysis, 2021 - Wiley Online Library
Systemic anticoagulation in maintenance hemodialysis (HD) has historically been
considered necessary to maintain the extracorporeal circuit (ECC) and preserve dialysis …

Risk factors and management of osteoporosis post-transplant

K Kovvuru, SR Kanduri, P Vaitla, R Marathi, S Gosi… - Medicina, 2020 - mdpi.com
Bone and mineral disorders are common after organ transplantation. Osteoporosis post
transplantation is associated with increased morbidity and mortality. Pathogenesis of bone …

Endothelial membrane mimetic coating modified dialyzer for hemocompatible and anticoagulant-free hemodialysis

C Sun, Q Yang, Y Li, R Li, P Yi, X Dang, S Wei… - Journal of Membrane …, 2024 - Elsevier
Current hemodialysis requires a dilemmatic balance between under-and over-
heparinization to prevent extracorporeal circuit clotting and bleeding complications. Here we …

Bone and mineral disorder in renal transplant patients: overview of pathology, clinical, and therapeutic aspects

P Molinari, CM Alfieri, D Mattinzoli, M Campise… - Frontiers in …, 2022 - frontiersin.org
Renal transplantation (RTx) allows us to obtain the resolution of the uremic status but is not
frequently able to solve all the metabolic complications present during end-stage renal …

Associations between stroke type, stroke severity, and pre-stroke osteoporosis with the risk of post-stroke fracture: A nationwide population-based study

HP Wang, SF Sung, HY Yang, WT Huang… - Journal of the …, 2021 - Elsevier
Background Recognizing the post-stroke fracture risk factors is crucial for targeted
intervention and primary fracture prevention. We aimed to investigate whether stroke types …