The genetic dissection of major depressive disorder (MDD) ranks as one of the success
stories of psychiatric genetics, with genome-wide association studies (GWAS) identifying …

The odds ratio (OR) for gender differences in major depression is 1.95, averaged meta-
analytically over all ages and nations. The gender difference appears by age 12, OR= 2.37 …

Minimal phenotyping refers to the reliance on the use of a small number of self-reported
items for disease case identification, increasingly used in genome-wide association studies …

Major depressive disorder (MDD) is a common, debilitating, phenotypically heterogeneous
disorder with heritability ranges from 30% to 50%. Compared to other psychiatric disorders …

With progress in genome-wide association studies of depression, from identifying zero hits
in~ 16 000 individuals in 2013 to 223 hits in more than a million individuals in 2020 …

Genetics provides two major opportunities for understanding human disease—as a
transformative line of etiological inquiry and as a biomarker for heritable diseases. In …

Mood disorders are highly prevalent and are the leading cause of disability worldwide. The
neurobiological mechanisms underlying depression remain poorly understood, although …

Depression is more frequent among individuals exposed to traumatic events. Both trauma
exposure and depression are heritable. However, the relationship between these traits …

Major depression (MD) is a heterogeneous disorder; however, the extent to which genetic
factors distinguish MD patient subgroups (genetic heterogeneity) remains uncertain. This …

Major depressive disorder (MDD) is currently the main cause of disability worldwide, but its
pathophysiology remains largely unknown, especially given its high heterogeneity in terms …