Consequences of Rab GTPase dysfunction in genetic or acquired human diseases
MJ Banworth, G Li - Small GTPases, 2018 - Taylor & Francis
Rab GTPases are important regulators of intracellular membrane trafficking in eukaryotes.
Both activating and inactivating mutations in Rab genes have been identified and implicated …
Both activating and inactivating mutations in Rab genes have been identified and implicated …
Impact of p85α alterations in cancer
JDS Marshall, DE Whitecross, P Mellor, DH Anderson - Biomolecules, 2019 - mdpi.com
The phosphatidylinositol 3-kinase (PI3K) pathway plays a central role in the regulation of
cell signaling, proliferation, survival, migration and vesicle trafficking in normal cells and is …
cell signaling, proliferation, survival, migration and vesicle trafficking in normal cells and is …
[HTML][HTML] Hypoxia promotes Rab5 activation, leading to tumor cell migration, invasion and metastasis
P Silva, P Mendoza, S Rivas, J Díaz, C Moraga… - Oncotarget, 2016 - ncbi.nlm.nih.gov
Hypoxia, a common condition of the tumor microenvironment, is associated with poor patient
prognosis, tumor cell migration, invasion and metastasis. Recent evidence suggests that …
prognosis, tumor cell migration, invasion and metastasis. Recent evidence suggests that …
Nuclear accumulation of β‐catenin is associated with endosomal sequestration of the destruction complex and increased activation of Rab5 in oral dysplasia
M Reyes, D Peña‐Oyarzún, P Silva… - The FASEB …, 2020 - Wiley Online Library
Potentially malignant lesions, commonly referred to as dysplasia, are associated with
malignant transformation by mechanisms that remain unclear. We recently reported that …
malignant transformation by mechanisms that remain unclear. We recently reported that …
Cancer-driving mutations and variants of components of the membrane trafficking core machinery
CQY Yong, BL Tang - Life Sciences, 2021 - Elsevier
The core machinery for vesicular membrane trafficking broadly comprises of coat proteins,
RABs, tethering complexes and SNAREs. As cellular membrane traffic modulates key …
RABs, tethering complexes and SNAREs. As cellular membrane traffic modulates key …
Nuclear accumulation of beta-catenin is associated with endosomal sequestration of the destruction complex and increased activation of Rab5 in oral dysplasia
M Reyes Rojas, D Peña Oyarzún, P Silva, S Venegas… - 2020 - repositorio.uchile.cl
Potentially malignant lesions, commonly referred to as dysplasia, are associated with
malignant transformation by mechanisms that remain unclear. We recently reported that …
malignant transformation by mechanisms that remain unclear. We recently reported that …
Efecto de PGE2 en la activación de la GTPasa pequeña Rab5 y en la internalización de E-cadherina en células HT29 de adenocarcinoma colorrectal
S Venegas Uribe - 2020 - repositorio.uchile.cl
Introducción: Prostaglandina E2 (PGE2) es un lípido que ejerce una serie de funciones
biológicas y ha sido implicada en distintos aspectos de la progresión tumoral. La pérdida de …
biológicas y ha sido implicada en distintos aspectos de la progresión tumoral. La pérdida de …
Papel de la gtpasa endosomal rab5 en la localización nuclear de β-catenina en displasia oral
MÁ Reyes Rojas - 2019 - repositorio.uchile.cl
La displasia oral reúne un conjunto de alteraciones celulares y tisulares en el epitelio oral,
cuyo diagnóstico está generalmente relacionado con una mayor tasa de transformación …
cuyo diagnóstico está generalmente relacionado con una mayor tasa de transformación …