Fibroblasts in cancer: Unity in heterogeneity

Y Chhabra, AT Weeraratna - Cell, 2023 - cell.com
Tumor cells do not exist in isolation in vivo, and carcinogenesis depends on the surrounding
tumor microenvironment (TME), composed of a myriad of cell types and biophysical and …

The role of the extracellular matrix in cancer stemness

S Nallanthighal, JP Heiserman… - Frontiers in cell and …, 2019 - frontiersin.org
As our understanding of cancer cell biology progresses, it has become clear that tumors are
a heterogenous mixture of different cell populations, some of which contain so called …

Tumor exosome-based nanoparticles are efficient drug carriers for chemotherapy

T Yong, X Zhang, N Bie, H Zhang, X Zhang, F Li… - Nature …, 2019 - nature.com
Developing biomimetic nanoparticles without loss of the integrity of proteins remains a major
challenge in cancer chemotherapy. Here, we develop a biocompatible tumor-cell …

Tumor-repopulating cells induce PD-1 expression in CD8+ T cells by transferring kynurenine and AhR activation

Y Liu, X Liang, W Dong, Y Fang, J Lv, T Zhang… - Cancer cell, 2018 - cell.com
Despite the clinical successes fostered by immune checkpoint inhibitors, mechanisms
underlying PD-1 upregulation in tumor-infiltrating T cells remain an enigma. Here, we show …

Advances in multicellular spheroids formation

X Cui, Y Hartanto, H Zhang - Journal of the Royal …, 2017 - royalsocietypublishing.org
Three-dimensional multicellular spheroids (MCSs) have a complex architectural structure,
dynamic cell–cell/cell–matrix interactions and bio-mimicking in vivo microenvironment. As a …

Biomimetic hydrogel supports initiation and growth of patient-derived breast tumor organoids

E Prince, J Cruickshank, W Ba-Alawi… - Nature …, 2022 - nature.com
Patient-derived tumor organoids (PDOs) are a highly promising preclinical model that
recapitulates the histology, gene expression, and drug response of the donor patient tumor …

Transcription upregulation via force-induced direct stretching of chromatin

A Tajik, Y Zhang, F Wei, J Sun, Q Jia, W Zhou… - Nature materials, 2016 - nature.com
Mechanical forces play critical roles in the function of living cells. However, the underlying
mechanisms of how forces influence nuclear events remain elusive. Here, we show that …

Hydrogel microenvironments for cancer spheroid growth and drug screening

Y Li, E Kumacheva - Science advances, 2018 - science.org
Multicellular cancer spheroids (MCSs) have emerged as a promising in vitro model that
replicates many features of solid tumors in vivo. Biomimetic hydrogel scaffolds for MCS …

Impact of the physical microenvironment on tumor progression and metastasis

F Spill, DS Reynolds, RD Kamm, MH Zaman - Current opinion in …, 2016 - Elsevier
Highlights•Physical cues from the tumor microenvironment strongly affect cancer cell
behavior.•Novel techniques increasingly help to capture those cues in vitro.•Mechanisms for …

Biophysics in tumor growth and progression: from single mechano-sensitive molecules to mechanomedicine

Y Xin, K Li, M Huang, C Liang, D Siemann, L Wu, Y Tan… - Oncogene, 2023 - nature.com
Evidence from physical sciences in oncology increasingly suggests that the interplay
between the biophysical tumor microenvironment and genetic regulation has significant …