The comparison of the immunological state of pregnancy to an immunosuppressed host–
graft model continues to lead research and clinical practice to ill-defined approaches. This …

Epidemiological data indicate a constant worldwide increase in cancer mortality, although
the age of onset is increasing. Recent accumulation of genomic data on human cancer via …

BACKGROUND Although the immune system intuitively must have an important role in
embryo implantation and in the achievement of a pregnancy, the molecular details have for …

In mammals, the placenta mediates maternal–fetal nutrient and waste exchange and acts in
an immunomodulatory way to facilitate maternal–fetal tolerance. The placenta is highly …

Immunotherapy is the new trend in cancer treatment due to the selectivity, long lasting
effects, and demonstrated improved overall survival and tolerance, when compared to …

Breast cancer during pregnancy (PrBC) is a rare tumor with only a little information on its
immune landscape. Here, we sought to characterize the cellular composition of the tumor …

Abstract Introduction Pluripotent stem cells (PSCs) are promising tools for modern
regenerative medicine applications because of their stemness properties, which include …

The maternal-fetal interface shares similarities with tumor tissues in terms of the immune
microenvironment. Normal pregnancy is maintained due to the immunosuppressed state …

Repeated implantation failure (RIF) was mainly due to poor endometrium receptivity. Long
noncoding RNAs (lncRNAs) could regulate endometrium receptivity and act in competing …

Tregs are crucial for maintaining maternal immunotolerance against the semiallogeneic
fetus. We investigated the elusive transcriptional profile and functional adaptation of human …