[HTML][HTML] Optimizing CRISPR/Cas9 precision: Mitigating off-target effects for safe integration with photodynamic and stem cell therapies in cancer treatment

JPJ Merlin, H Abrahamse - Biomedicine & Pharmacotherapy, 2024 - Elsevier
CRISPR/Cas9 precision genome editing has revolutionized cancer treatment by introducing
specific alterations to the cancer genome. But the therapeutic potential of CRISPR/Cas9 is …

[HTML][HTML] Combining Photodynamic Therapy and Targeted Drug Delivery Systems: Enhancing Mitochondrial Toxicity for Improved Cancer Outcomes

JPJ Merlin, A Crous, H Abrahamse - International journal of molecular …, 2024 - mdpi.com
Cancer treatment continues to be a substantial problem due to tumor complexities and
persistence, demanding novel therapeutic techniques. This review investigates the …

Compatibility study between ferulic acid and excipients used in cosmetic formulations by TG/DTG, DSC and FTIR

GSN Bezerra, MAV Pereira, EA Ostrosky… - Journal of Thermal …, 2017 - Springer
Abstract Ferulic acid (4-hydroxy-3-methoxycinnamic acid) is a phytochemical constituent
from the polyphenols group commonly found in whole grains, spinach, parsley, grapes and …

Advancing Photodynamic Therapy with Nano-Conjugated Hypocrellin: Mechanisms and Clinical Applications

SS Rajan, R Chandran… - International Journal of …, 2024 - Taylor & Francis
Hypocrellin-based photodynamic therapy (PDT) is developing as a viable cancer
therapeutic option, especially when enhanced by nanoconjugation. This review investigates …

A novel serum-stable liver targeted cytotoxic system using valerate-conjugated chitosan nanoparticles surface decorated with glycyrrhizin

EM El-Marakby, RM Hathout, I Taha, S Mansour… - International journal of …, 2017 - Elsevier
The aim of this study was to target a naturally chemotherapeutic agent: ferulic acid to the
liver using a biocompatible and an in vivo stable carrier. Accordingly, chitosan as a …

[HTML][HTML] Phytochemical and Biological Investigations of Crude Extracts of Astragalus pisidicus

E Aydemir, E Odabaş Köse, S Özkaya Gül, A Korkut… - Pharmaceuticals, 2024 - mdpi.com
Background/Objectives: Astragalus L. is a genus of the Fabaceae family, encompassing
over 3000 species globally, with 380 species found in Turkey. This is the inaugural …

Supramolecular self-assembly and perfected in vitro/vivo property of 5-fluorouracil and ferulic acid on the strength of double optimized strategy: the first 5-fluorouracial …

YM Yu, YY Niu, LY Wang, YT Li, ZY Wu, CW Yan - Analyst, 2021 - pubs.rsc.org
For highlighting the predominance of phenolic acid nutraceutical ferulic acid (FR) in
regulating the in vivo/vitro performances of anticancer drug 5-fluorouracil (Flu) and …

Overcoming challenges in cancer treatment: Nano‐enabled photodynamic therapy as a viable solution

SS Rajan, R Chandran… - Wiley Interdisciplinary …, 2024 - Wiley Online Library
Cancer presents a formidable challenge, necessitating innovative therapies that maximize
effectiveness while minimizing harm to healthy tissues. Nanotechnology has emerged as a …

Molecular insights and therapeutic implications of nanoengineered dietary polyphenols for targeting lung carcinoma: part I

SS Das, S Tambe, PR Prasad Verma, P Amin… - …, 2022 - Taylor & Francis
Lung cancer is the second leading cause of cancer-related mortality globally, and non-small-
cell lung cancer accounts for most lung cancer cases. Nanotechnology-based drug-delivery …

PEG-Fmoc-ibuprofen conjugate as a dual functional nanomicellar carrier for paclitaxel

M Zhao, Y Huang, Y Chen, J Xu, S Li… - Bioconjugate …, 2016 - ACS Publications
Ibuprofen is a kind of nonsteroidal anti-inflammatory drug (NSAIDs), and it is considered to
possess some antitumor effect. In this study, a novel nanomicellar carrier based on PEG …