Metabolism pathways of arachidonic acids: mechanisms and potential therapeutic targets
The arachidonic acid (AA) pathway plays a key role in cardiovascular biology,
carcinogenesis, and many inflammatory diseases, such as asthma, arthritis, etc. Esterified …
carcinogenesis, and many inflammatory diseases, such as asthma, arthritis, etc. Esterified …
Amino-pyrazoles in medicinal chemistry: A review
M Lusardi, A Spallarossa, C Brullo - International journal of molecular …, 2023 - mdpi.com
A pyrazole nucleus is an easy-to-prepare scaffold with large therapeutic potential.
Consequently, the search for new pyrazole-based compounds is of great interest to the …
Consequently, the search for new pyrazole-based compounds is of great interest to the …
Selective COX-2 inhibitors: road from success to controversy and the quest for repurposing
The introduction of selective COX-2 inhibitors (so-called 'coxibs') has demonstrated
tremendous commercial success due to their claimed lower potential of serious …
tremendous commercial success due to their claimed lower potential of serious …
Design, synthesis, and anti-inflammatory activity of some coumarin Schiff base derivatives: In silico and in vitro study
Introduction Inflammation is a fundamental response of the immune system during tissue
damage or pathogen infection to protect and maintain tissue homeostasis. However …
damage or pathogen infection to protect and maintain tissue homeostasis. However …
Identification of new rofecoxib-based cyclooxygenase-2 inhibitors: A bioinformatics approach
RP Leão, JV Cruz, GV da Costa, JN Cruz… - Pharmaceuticals, 2020 - mdpi.com
The cyclooxygenase-2 receptor is a therapeutic target for planning potential drugs with anti-
inflammatory activity. The selective cyclooxygenase-2 (COX-2) inhibitor rofecoxib was …
inflammatory activity. The selective cyclooxygenase-2 (COX-2) inhibitor rofecoxib was …
Novel pyrazole-based COX-2 inhibitors as potential anticancer agents: Design, synthesis, cytotoxic effect against resistant cancer cells, cell cycle arrest, apoptosis …
Novel differently substituted pyrazole derivatives were designed, synthesized and evaluated
for their anticancer activity. All compounds selectively inhibited COX-2 enzyme (IC 50 …
for their anticancer activity. All compounds selectively inhibited COX-2 enzyme (IC 50 …
The indole nucleus as a selective COX-2 inhibitor and anti-inflammatory agent (2011–2022)
Here we have outlined the recent (2011–2022) developments in the synthesis of modified
indomethacin-based analogues for the selective inhibition of COX-2 and then highlighted …
indomethacin-based analogues for the selective inhibition of COX-2 and then highlighted …
Anti-inflammatory activity and ROS regulation effect of sinapaldehyde in LPS-stimulated RAW 264.7 macrophages
SH Baek, T Park, MG Kang, D Park - Molecules, 2020 - mdpi.com
We evaluated the anti-inflammatory effects of SNAH in lipopolysaccharide (LPS)-stimulated
RAW 264.7 macrophages by performing nitric oxide (NO) assays, cytokine enzyme-linked …
RAW 264.7 macrophages by performing nitric oxide (NO) assays, cytokine enzyme-linked …
The prognostic value of arachidonic acid metabolism in breast cancer by integrated bioinformatics
W Li, X Guo, C Chen, J Li - Lipids in Health and Disease, 2022 - Springer
Background As the second cause of cancer death in women, breast cancer has become a
worldwide priority. Previous studies based on tumour cell lines demonstrated that …
worldwide priority. Previous studies based on tumour cell lines demonstrated that …
Design, synthesis and biological assessment of new selective COX-2 inhibitors including methyl sulfonyl moiety
Nonsteroidal anti-inflammatory drugs (NSAIDs) cause peptic lesions in the gastrointestinal
mucosa by inhibiting the cyclooxygenase-1 (COX-1) enzyme. Selective COX-2 inhibition …
mucosa by inhibiting the cyclooxygenase-1 (COX-1) enzyme. Selective COX-2 inhibition …