Epithelial–mesenchymal transition (EMT) has been implicated in various aspects of tumor
development, including tumor invasion and metastasis, cancer stemness, and therapy …

Zinc finger proteins are transcription factors with the finger domain, which plays a significant
role in gene regulation. As the largest family of transcription factors in the human genome …

Transitory phenotypic changes such as the epithelial–mesenchymal transition (EMT) help
embryonic cells to generate migratory descendants that populate new sites and establish …

The global prevalence of nonalcoholic fatty liver disease (NAFLD) continues to rise, yet
effective treatments are lacking due to the complex pathogenesis of this disease. Although …

The transcription factor GLI3 is a member of the Hedgehog (Hh/HH) signaling pathway that
can exist as a full length (Gli3-FL/GLI3-FL) or repressor (Gli3-R/GLI3-R) form. In response to …

Abstract Tuftelin1 (TUFT1), an acidic protein constituent of developing and mineralizing
tooth tissues, is regulated by hypoxia and the Hedgehog signaling pathway. We investigated …

Background The E3 ubiquitin ligase Fbxw7 functions as a general tumor suppressor by
targeting several well-known oncoproteins for ubiquitination and proteasomal degradation …

Abstract miR-187-3p, a novel cancer-related microRNA, was previously reported to play
promoting or suppressive roles in different malignancies. However, the expression level …

Background & Aims: To investigate the expression and prognostic value of MACC1 in
patients with HCC and identify the mechanism by which MACC1 inhibits HCC cell apoptosis …

Purpose Hepatocellular carcinoma (HCC) accounts for more than 80% of primary liver
cancers and is one of the leading causes of cancer-related death in many countries. Cancer …