Connexin43 as a tumor suppressor: Proposed Connexin43 mRNA-circularRNAs-microRNAs axis towards prevention and early detection in breast cancer

N Naser Al Deen, M AbouHaidar, R Talhouk - Frontiers in medicine, 2019 - frontiersin.org
Breast cancer (BC) is a global public health burden, constituting the highest cancer
incidence in women worldwide. Connexin43 (Cx43) is a member of a family of …

Context dependent reversion of tumor phenotype by connexin-43 expression in MDA-MB231 cells and MCF-7 cells: Role of β-catenin/connexin43 association

RS Talhouk, MB Fares, GJ Rahme, HH Hariri… - Experimental cell …, 2013 - Elsevier
Abstract Connexins (Cx), gap junction (GJ) proteins, are regarded as tumor suppressors,
and Cx43 expression is often down regulated in breast tumors. We assessed the effect of …

Connexin 43 loss triggers cell cycle entry and invasion in non-neoplastic breast epithelium: a role for noncanonical Wnt signaling

S Fostok, M El-Sibai, D Bazzoun, S Lelièvre, R Talhouk - Cancers, 2019 - mdpi.com
(1) Background: The expression of connexin 43 (Cx43) is disrupted in breast cancer, and re-
expression of this protein in human breast cancer cell lines leads to decreased proliferation …

Gap junctions and Wnt signaling in the mammary gland: a cross-talk?

SF Fostok, M El-Sibai, M El-Sabban… - Journal of mammary gland …, 2019 - Springer
Connexins (Cxs), the building blocks of gap junctions (GJs), exhibit spatiotemporal patterns
of expression and regulate the development and differentiation of the mammary gland …

[PDF][PDF] Deciphering mRNA-circRNA-miRNA axes and miRNA regulators in early breast cancer using a breast epithelial risk-progression 3D culture model

N Naser Al Deen - 2020 - scholarworks.aub.edu.lb
Breast Cancer accounts for the highest cancer incidence and mortality rate in women
worldwide [1]. In Lebanon, breast cancer is the most common malignancy, with the highest …

[引用][C] ENHANCING MIR-183-5P ABUNDANCE IN RODENT MAMMARY EPITHELIAL CELLS: EFFECT ON DIFFERENTIATION

R Kalot - 2021