Effects of pulsed, spatially fractionated, microscopic synchrotron X-ray beams on normal and tumoral brain tissue

E Bräuer-Krisch, R Serduc, EA Siegbahn… - … Research/Reviews in …, 2010 - Elsevier
Microbeam radiation therapy (MRT) uses highly collimated, quasi-parallel arrays of X-ray
microbeams of 50–600keV, produced by third generation synchrotron sources, such as the …

Clinical applications of iron oxide nanoparticles for magnetic resonance imaging of brain tumors

M Iv, N Telischak, D Feng, SJ Holdsworth… - …, 2015 - Taylor & Francis
Current neuroimaging provides detailed anatomic and functional evaluation of brain tumors,
allowing for improved diagnostic and prognostic capabilities. Some challenges persist even …

A global analysis of viviparity in squamates highlights its prevalence in cold climates

A Zimin, SV Zimin, R Shine, L Avila… - Global Ecology and …, 2022 - Wiley Online Library
Aim Viviparity has evolved more times in squamates than in any other vertebrate group;
therefore, squamates offer an excellent model system in which to study the patterns, drivers …

Preferential effect of synchrotron microbeam radiation therapy on intracerebral 9L gliosarcoma vascular networks

A Bouchet, B Lemasson, G Le Duc, C Maisin… - International Journal of …, 2010 - Elsevier
PURPOSE: Synchrotron microbeam radiation therapy (MRT) relies on spatial fractionation of
the incident photon beam into parallel micron-wide beams. Our aim was to analyze the …

[HTML][HTML] Proton minibeam radiation therapy reduces side effects in an in vivo mouse ear model

S Girst, C Greubel, J Reindl, C Siebenwirth… - International Journal of …, 2016 - Elsevier
Purpose Proton minibeam radiation therapy is a novel approach to minimize normal tissue
damage in the entrance channel by spatial fractionation while keeping tumor control through …

[HTML][HTML] Microbeam radiation therapy: Clinical perspectives

MA Grotzer, E Schültke, E Bräuer-Krisch, JA Laissue - Physica Medica, 2015 - Elsevier
Microbeam radiation therapy (MRT), a novel form of spatially fractionated radiotherapy (RT),
uses arrays of synchrotron-generated X-ray microbeams (MB). MRT has been identified as a …

Tumor cell response to synchrotron microbeam radiation therapy differs markedly from cells in normal tissues

JC Crosbie, RL Anderson, K Rothkamm… - International Journal of …, 2010 - Elsevier
PURPOSE: High-dose synchrotron microbeam radiation therapy (MRT) can be effective at
destroying tumors in animal models while causing very little damage to normal tissues. The …

Microbeam radiation therapy—grid therapy and beyond: a clinical perspective

E Schültke, J Balosso, T Breslin… - The British journal of …, 2017 - academic.oup.com
Microbeam irradiation is spatially fractionated radiation on a micrometer scale. Microbeam
irradiation with therapeutic intent has become known as microbeam radiation therapy …

A matter of space: how the spatial heterogeneity in energy deposition determines the biological outcome of radiation exposure

G Baiocco, S Bartzsch, V Conte, T Friedrich… - Radiation and …, 2022 - Springer
The outcome of the exposure of living organisms to ionizing radiation is determined by the
distribution of the associated energy deposition at different spatial scales. Radiation …

Synchrotron microbeam radiation therapy for rat brain tumor palliation—influence of the microbeam width at constant valley dose

R Serduc, A Bouchet, E Bräuer-Krisch… - Physics in Medicine …, 2009 - iopscience.iop.org
To analyze the effects of the microbeam width (25, 50 and 75 µm) on the survival of 9L
gliosarcoma tumor-bearing rats and on toxicity in normal tissues in normal rats after …