Flavin‐Dependent Nitroreductases: Privileged Enzymes for Chemical and Photochemical Synthesis

S Russo, AP Luján, MW Fraaije… - ChemCatChem, 2024 - Wiley Online Library
Nitroreductases, present within both prokaryotes and eukaryotes, form a group of flavin‐
dependent enzymes capable of reducing nitro compounds using NAD (P) H as reducing …

Synthesis of novel nitroreductase enzyme-activated nitric oxide prodrugs to site-specifically kill bacteria

HAJ Hibbard, MM Reynolds - Bioorganic Chemistry, 2019 - Elsevier
The developing antibiotic resistance crisis creates a serious need for new antimicrobial
agents. In this work, novel nitroaromatic-protected piperazine diazeniumdiolate (nitric oxide …

[HTML][HTML] Automatable downstream purification of the benzohydroxamic acid D-DIBOA from a biocatalytic synthesis

ME de la Calle, G Cabrera, T Linares-Pineda… - New …, 2022 - Elsevier
Herbicides play a vital role in agriculture, contributing to increased crop productivity by
minimizing weed growth, but their low degradability presents a threat to the environment and …

Efficient bio-reduction of 3-nitro phthalic acid using engineered nitroreductase and V2O5

Q Zhang, Y Feng, X Liang, S Wu, F He, Y Guan… - Process …, 2025 - Elsevier
In this study, a potent nitroreductase enzyme was successfully identified and engineered,
which was then employed in an efficient and environmentally friendly chemo-bio …

Synthetic approach to new 2H-benzo [b][1, 4] oxazin-3-one derivatives containing 1, 2, 3-triazole by click chemistry

A Darifa, I Aziz, L Saliha, A Khalid, E Mohamed… - Tetrahedron, 2024 - Elsevier
Owing to the biological importance of 1, 2, 3-triazoles and benzoxazine-3 (4H)-ones
scaffolds, we have attempted to design and synthesize novel 1, 2, 3-traizoles linked to …

A genetically engineered Escherichia coli strain overexpressing the nitroreductase NfsB is capable of producing the herbicide D-DIBOA with 100% molar yield

ME de la Calle, G Cabrera, D Cantero, A Valle… - Microbial Cell …, 2019 - Springer
Background The use of chemical herbicides has helped to improve agricultural production,
although its intensive use has led to environmental damages. Plant allelochemicals are …

optimization of the biocatalysis for D-DIBOA synthesis using a quick and sensitive new spectrophotometric quantification method

G Cabrera, T Linares, ME de la Calle… - International Journal of …, 2020 - mdpi.com
D-DIBOA (4-hydroxy-(2H)-1, 4-benzoxazin-3-(4H)-one) is an allelopathic-derived compound
with interesting herbicidal, fungicidal, and insecticide properties whose production has been …

Automatable downstream purification of the benzohydroxamic acid D-DIBOA from a biocatalytic synthesis

ME Calle Sierra, G Cabrera Revuelta… - 2022 - rodin.uca.es
Herbicides play a vital role in agriculture, contributing to increased crop productivity by
minimizing weed growth, but their low degradability presents a threat to the environment and …

Optimization of the Biocatalysis for D-DIBOA Synthesis Using a Quick and Sensitive New Spectrophotometric Quantification Method

G Cabrera Revuelta, T Linares-Pineda, ME de la Calle… - 2020 - rodin.uca.es
D-DIBOA (4-hydroxy-(2H)-1, 4-benzoxazin-3-(4H)-one) is an allelopathic-derived compound
with interesting herbicidal, fungicidal, and insecticide properties whose production has been …