Chronic obstructive pulmonary disease (COPD) is a deadly and highly morbid disease.
Susceptibility to and heterogeneity of COPD are incompletely explained by environmental …

Aberrant splicing underlies many human diseases, including cancer, cardiovascular
diseases and neurological disorders. Genome-wide mapping of splicing quantitative trait …

The resources generated by the GTEx consortium offer unprecedented opportunities to
advance our understanding of the biology of human diseases. Here, we present an in-depth …

The kidney is an organ of key relevance to blood pressure (BP) regulation, hypertension and
antihypertensive treatment. However, genetically mediated renal mechanisms underlying …

Background Given the differences in embryonic origin, vascular and nervous supplies,
microbiotic burden, and main physiological functions of left and right colons, tumor location …

Macrophages are highly plastic cells that differentially regulate multiple pathological
conditions, including cancer and autoimmune diseases. In response to various stimuli …

Alternate splicing events can create isoforms that alter gene function, and genetic variants
associated with alternate gene isoforms may reveal molecular mechanisms of disease. We …

Abstract Beta-2 adrenergic receptors (β2-ARs) have important roles in the pathogenesis and
treatment of chronic obstructive pulmonary disease (COPD). In recent years, progress has …

In many learning problems, the domain scientist is often interested in discovering the groups
of features that are redundant and are important for classification. Moreover, the features that …

Understanding pre-mRNA splicing is crucial to accurately diagnosing and treating genetic
diseases. However, mutations that alter splicing can exert highly diverse effects. Of all the …