The aryl hydrocarbon receptor (AhR) was initially identified as the receptor that binds and
mediates the toxic effects induced by 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (TCDD) and …

The aryl hydrocarbon receptor (AhR) is a ligand-activated transcriptional factor (TF) that is a
member of the Per-Arnt-Sim family of proteins. AhR regulates diverse processes, including …

Although practiced clinically for more than 40 years, the use of hematopoietic stem cell
(HSC) transplants remains limited by the ability to expand these cells ex vivo. An unbiased …

Inflammatory signaling plays a key role in tumor progression, and the pleiotropic cytokine
interleukin-6 (IL-6) is an important mediator of protumorigenic properties. Activation of the …

SIRT6 belongs to the sirtuin family of protein lysine deacetylases, which regulate aging and
genome stability. We found that human SIRT6 has a role in promoting DNA end resection, a …

TCDD-mediated toxicity of human individuals together with animal studies led to
identification of the aryl hydrocarbon receptor (AHR). It was characterized as multifunctional …

The aryl hydrocarbon receptor (AhR) belongs to the basic helix-loop-helix family of DNA-
binding proteins that play a role in the toxicity and carcinogenicity of certain chemicals. The …

The aryl hydrocarbon receptor (AHR) plays an important physiological role in
hematopoiesis. AHR is highly expressed in hematopoietic stem and progenitor cells …

Processes that regulate quiescence, self‐renewal, and differentiation of hematopoietic stem
cells (HSCs) are not well understood. Owing, in part, to the ability of xenobiotic ligands to …

Loss of immune function and increased hematopoietic disease are among the most clinically
significant consequences of aging. Hematopoietic stem cells (HSCs) from mice lacking aryl …