[HTML][HTML] Inflammation and atherosclerosis: signaling pathways and therapeutic intervention

P Kong, ZY Cui, XF Huang, DD Zhang… - Signal transduction and …, 2022 - nature.com
Atherosclerosis is a chronic inflammatory vascular disease driven by traditional and
nontraditional risk factors. Genome-wide association combined with clonal lineage tracing …

How the immune system shapes atherosclerosis: roles of innate and adaptive immunity

P Roy, M Orecchioni, K Ley - Nature Reviews Immunology, 2022 - nature.com
Atherosclerosis is the root cause of many cardiovascular diseases. Extensive research in
preclinical models and emerging evidence in humans have established the crucial roles of …

[HTML][HTML] Autophagy, pyroptosis, and ferroptosis: new regulatory mechanisms for atherosclerosis

L Lin, MX Zhang, L Zhang, D Zhang, C Li… - Frontiers in cell and …, 2022 - frontiersin.org
Atherosclerosis is a chronic inflammatory disorder characterized by the gradual buildup of
plaques within the vessel wall of middle-sized and large arteries. The occurrence and …

[HTML][HTML] Immune clearance of senescent cells to combat ageing and chronic diseases

P Song, J An, MH Zou - Cells, 2020 - mdpi.com
Senescent cells are generally characterized by permanent cell cycle arrest, metabolic
alteration and activation, and apoptotic resistance in multiple organs due to various …

Innate and adaptive immunity: the understudied driving force of heart valve disease

F Bartoli-Leonard, J Zimmer… - Cardiovascular research, 2021 - academic.oup.com
Calcific aortic valve disease (CAVD), and its clinical manifestation that is calcific aortic valve
stenosis, is the leading cause for valve disease within the developed world, with no current …

MicroRNA-mediated autophagy regulation in cancer therapy: the role in chemoresistance/chemosensitivity

M Ashrafizadeh, A Zarrabi, S Orouei… - European Journal of …, 2021 - Elsevier
Chemoresistance has doubled the effort needed to reach an effective treatment for cancer.
Now, scientists should consider molecular pathways and mechanisms involved in …

[HTML][HTML] Targeting senescent cells to attenuate cardiovascular disease progression

P Song, Q Zhao, MH Zou - Ageing research reviews, 2020 - Elsevier
Cardiovascular disease (CVD) is the most common disease to increase as life expectancy
increases. Most high-profile pharmacological treatments for age-related CVD have led to …

[HTML][HTML] Berberine-induced TFEB deacetylation by SIRT1 promotes autophagy in peritoneal macrophages

Y Zheng, J Kou, P Wang, T Ye, Z Wang, Z Gao… - Aging (Albany …, 2021 - ncbi.nlm.nih.gov
Atherosclerosis is a chronic inflammatory disease that commonly affects the elderly and is
characterized by vascular damage, macrophage infiltration, and plaque formation …

[HTML][HTML] The why and how of adaptive immune responses in ischemic cardiovascular disease

Z Mallat, CJ Binder - Nature cardiovascular research, 2022 - nature.com
Atherosclerotic cardiovascular disease is a major cause of disability and death worldwide.
Most therapeutic approaches target traditional risk factors but ignore the fundamental role of …

[HTML][HTML] The dual roles of autophagy and the GPCRs-mediating autophagy signaling pathway after cerebral ischemic stroke

W Hou, Y Hao, L Sun, Y Zhao, X Zheng, L Song - Molecular Brain, 2022 - Springer
Ischemic stroke, caused by a lack of blood supply in brain tissues, is the third leading cause
of human death and disability worldwide, and usually results in sensory and motor …