ER stress and the unfolded protein response in neurodegeneration
The clinical manifestation of neurodegenerative diseases is initiated by the selective
alteration in the functionality of distinct neuronal populations. The pathology of many …
alteration in the functionality of distinct neuronal populations. The pathology of many …
A lifetime of stress: ATF6 in development and homeostasis
RF Hillary, U FitzGerald - Journal of biomedical science, 2018 - Springer
Background Activating transcription factor 6 (ATF6) is an endoplasmic reticulum (ER)-
localised protein and member of the leucine zipper family of transcription factors. Best …
localised protein and member of the leucine zipper family of transcription factors. Best …
The role of endoplasmic reticulum stress in neurodegenerative disease
C Xiang, Y Wang, H Zhang, F Han - Apoptosis, 2017 - Springer
The endoplasmic reticulum (ER) is an important organelle involved in cellular homeostasis
and control of protein quality. Unfolded protein response (UPR) is a cellular response to ER …
and control of protein quality. Unfolded protein response (UPR) is a cellular response to ER …
CREB3 transcription factors: ER-golgi stress transducers as hubs for cellular homeostasis
L Sampieri, P Di Giusto, C Alvarez - Frontiers in cell and …, 2019 - frontiersin.org
CREB3 family of transcription factors are ER localized proteins that belong to the bZIP
family. They are transported from the ER to the Golgi, cleaved by S1P and S2P proteases …
family. They are transported from the ER to the Golgi, cleaved by S1P and S2P proteases …
Endoplasmic reticulum stress and therapeutic strategies in metabolic, neurodegenerative diseases and cancer
S Yuan, D She, S Jiang, N Deng, J Peng, L Ma - Molecular Medicine, 2024 - Springer
The accumulation of unfolded or misfolded proteins within the endoplasmic reticulum (ER),
due to genetic determinants and extrinsic environmental factors, leads to endoplasmic …
due to genetic determinants and extrinsic environmental factors, leads to endoplasmic …
[HTML][HTML] ATF6α downregulation of PPARα promotes lipotoxicity-induced tubulointerstitial fibrosis
Tubulointerstitial fibrosis is a strong predictor of progression in patients with chronic kidney
disease, and is often accompanied by lipid accumulation in renal tubules. However, the …
disease, and is often accompanied by lipid accumulation in renal tubules. However, the …
Impact of ER stress and ER-mitochondrial crosstalk in Huntington's disease
Accumulation of misfolded proteins is a common phenomenon of several
neurodegenerative diseases. The misfolding of proteins due to abnormal polyglutamine …
neurodegenerative diseases. The misfolding of proteins due to abnormal polyglutamine …
[HTML][HTML] Progress of immunotherapy of anti-α-synuclein in Parkinson's disease
Z Wang, G Gao, C Duan, H Yang - Biomedicine & Pharmacotherapy, 2019 - Elsevier
Many neurodegenerative diseases are characterized by progressive loss of neurons and
abnormal protein accumulation, including amyloid (A) β and tau in Alzheimer's disease and …
abnormal protein accumulation, including amyloid (A) β and tau in Alzheimer's disease and …
The Unfolded Protein Response: A Double-Edged Sword for Brain Health
Efficient brain function requires as much as 20% of the total oxygen intake to support normal
neuronal cell function. This level of oxygen usage, however, leads to the generation of free …
neuronal cell function. This level of oxygen usage, however, leads to the generation of free …
Repaglinide elicits a neuroprotective effect in rotenone-induced Parkinson's disease in rats: emphasis on targeting the DREAM-ER stress BiP/ATF6/CHOP trajectory …
Repaglinide, a meglitinide insulinotropic antidiabetic, was unraveled as a promising
therapeutic agent for Huntington's disease by targeting the neuronal calcium sensor …
therapeutic agent for Huntington's disease by targeting the neuronal calcium sensor …