Prostate cancer (PCa) is the second most diagnosed cancer in men worldwide. For its
screening, serum prostate specific antigen (PSA) test has been largely performed over the …

The development of the syndrome of cancer cachexia and that of metastasis are related with
a poor prognostic for cancer patients. They are considered multifactorial processes …

Abstract Hypoxia-inducible factor-1α (HIF-1α) is highly expressed/activated in most hypoxic
tumors including hepatocellular carcinoma (HCC). Another key transcription factor, nuclear …

MicroRNAs have been broadly implicated in cancer, but their exact function and mechanism
in carcinogenesis remain poorly understood. Aberrant miR-486-5p expression is frequently …

Type 2 diabetes mellitus and breast cancer are complex, chronic, heterogeneous, and multi-
factorial diseases; with common risk factors including but not limited to diet, obesity, and …

While autophagy is constitutively executed at basal level in all cells, it is activated in cancer
cells in response to various microenvironmental stresses including hypoxia. It is now well …

Background Resveratrol, a polyphenol found on the surface of red fruits, is able to suppress
many kinds of malignancies. Nevertheless, its mechanism of action is not yet clear …

Progression of prostate cancer depends on androgen receptor, which is usually activated by
androgens. Therefore, a mainstay treatment is androgen deprivation therapy. Unfortunately …

Background Therapeutic targeting of the androgen signaling pathway is a mainstay
treatment for prostate cancer. Although initially effective, resistance to androgen targeted …

MicroRNAs (miRNAs), a class of small noncoding RNA molecules, can manipulate the
expressions of endogenous tumor-related genes, and are implicated in the development …