Highlights•Exome sequencing on unprecedented scale has identified 400 genes associated
with ASD and NDD.•Functional networks disrupted in NDD converge on distinct …

Activity-driven transcription plays an important role in many brain processes, including those
underlying memory and epilepsy. Here we combine genetic tagging of nuclei and ribosomes …

Highlights•CBP and p300 (KAT3s) interact with dozens of TFs and acetylate hundreds of
substrates.•KAT3s have both unique and overlapping functions during neural …

Memory impairment is the main feature of Alzheimer's disease (AD). Initial impairments
originate in the temporal lobe area and propagate throughout the brain in a sequential …

The lysine acetyltransferases type 3 (KAT3) family members CBP and p300 are important
transcriptional co-activators, but their specific functions in adult post-mitotic neurons remain …

Kdm1a is a histone demethylase linked to intellectual disability with essential roles during
gastrulation and the terminal differentiation of specialized cell types, including neurons, that …

Environmental factors and life experiences impinge on brain circuits triggering adaptive
changes. Epigenetic regulators contribute to this neuroadaptation by enhancing or …

Introduction Growing evidence clearly demonstrates that maternal rodents exposure to sleep
deprivation (SD) during late pregnancy impairs learning and memory in their offspring …

Serum response factor (SRF) is a representative transcription factor that plays crucial roles
in various biological phenomena by regulating immediate early genes (IEGs) and genes …

Rubinstein-Taybi syndrome (RSTS) is a rare multisystem developmental disorder with
moderate to severe intellectual disability caused by heterozygous mutations of either …