The brain and nervous system are prone to oxidative stress, and are inadequately equipped
with antioxidant defense systems to prevent 'ongoing'oxidative damage, let alone the extra …

Hydroethidine (HE; or dihydroethidium) is the most popular fluorogenic probe used for
detecting intracellular superoxide radical anion. The reaction between superoxide and HE …

Oxidative stress is considered causal of aging and pathological cell death, however, very
little is known about its function in the natural processes that support the formation of an …

CLP1 was the first mammalian RNA kinase to be identified. However, determining its in vivo
function has been elusive. Here we generated kinase-dead Clp1 (Clp1 K/K) mice that show …

The molecular mechanisms underlying thiol-based redox control are poorly defined.
Disulfide bonds between Cys residues are commonly thought to confer extra rigidity and …

Reactive oxygen species (ROS), mostly derived from mitochondrial activity, can damage
various macromolecules and consequently cause cell death. This ROS activity has been …

More than half of the initially-formed neurons are deleted in certain brain regions during
normal development. This process, whereby cells are discretely removed without interfering …

The nervous system is especially vulnerable to reactive oxygen species (ROS)-mediated
injury for the following reasons.(1) High oxygen consumption of the brain for high energy …

Charcot first described amyotrophic lateral sclerosis (ALS) in 1869; however, its causes
remain largely unknown and effective, long‐term treatment strategies are not available. The …

Distal hereditary neuropathies and neuro motor diseases are complex neurological
phenotypes associated with pathogenic variants in a large number of genes, but in some the …