The endothelial cells lining the brain capillaries separate the blood from the brain
parenchyma. The endothelial monolayer of the brain capillaries serves both as a crucial …

Glucose transporters (GLUTs) at the blood-brain barrier maintain the continuous high
glucose and energy demands of the brain. They also act as therapeutic targets and provide …

Neurons need a continuous supply of glucose, the major source of energy for mammalian
brain metabolism. The central nervous system is protected by three main physiological cell …

Fructose is now such an important component of human diets that increasing attention is
being focused on the fructose transporter GLUT5. In this review, we describe the regulation …

While transport processes for amino acids and glucose have long been known to be
expressed in the luminal and abluminal membranes of the endothelium comprising the …

The most common cause of dementia, especially in elderly people, is Alzheimer's disease
(AD), with aging as its main risk factor. AD is a multifactorial neurodegenerative disease …

Neurological disorders have emerged as a predominant healthcare concern in recent years
due to their severe consequences on quality of life and prevalence throughout the world …

Ascorbic acid is a key antioxidant of the Central Nervous System (CNS). Under brain activity,
ascorbic acid is released from glial reservoirs to the synaptic cleft, where it is taken up by …

It has been proposed that the enhanced metabolic activity of tumor cells is accompanied by
an increased expression of facilitative hexose transporters (GLUTs). However, a previous …

The facilitated diffusion of glucose, galactose, fructose, urate, myoinositol, and
dehydroascorbic acid in mammals is catalyzed by a family of 14 monosaccharide transport …