In this review, we summarize current knowledge of perhaps one of the most intriguing
phenomena in cell biology: the mitochondrial permeability transition pore (mPTP). This …

Mitochondrial Ca 2+ regulation is crucial for bioenergetics and cellular signaling. The
mechanisms controlling mitochondrial calcium homeostasis have been recently unraveled …

Neurodegenerative diseases are a spectrum of chronic, debilitating disorders characterised
by the progressive degeneration and death of neurons. Mitochondrial dysfunction has been …

Adenosine triphosphate (ATP) is a universal mediator of metabolism and signaling across
unicellular and multicellular species. There is a fundamental interdependence between the …

Neurons have limited intracellular energy stores but experience acute and unpredictable
increases in energy demand. To better understand how these cells repeatedly transit from a …

Glutamate elicits Ca 2+ signals and workloads that regulate neuronal fate both in
physiological and pathological circumstances. Oxidative phosphorylation is required in …

Calcium is an important second messenger regulating a bioenergetic response to the
workloads triggered by neuronal activation. In embryonic mouse cortical neurons using …

The transfer of metabolites through the mitochondrial membranes is a vital process that is
highly controlled and regulated by the inner membrane. A variety of metabolites …

Genetic processes require the activity of multiple topoisomerases, essential enzymes that
remove topological tension and intermolecular linkages in DNA. We have investigated the …

Brain tissue metabolism is distributed across several cell types and subcellular
compartments, which activate at different times and with different temporal patterns. The …