The recent increase in outbreaks of pathogenic bacteria and antimicrobial resistance
represent major public health problems. Being the leading cause of death in humans, the …

To address the drug-resistance of bacterial pathogens without imposing a selective survival
pressure, virulence and biofilms are highly attractive targets. Here, we show that terrein …

The opportunistic human pathogen Pseudomonas aeruginosa expresses numerous acute
virulence factors in the initial phase of infection, and during long-term colonization it …

The opportunistic pathogen Burkholderia pseudomallei is a saprophytic bacterium and the
causative agent of melioidosis, an emerging infectious disease associated with high …

A transcriptome analysis identified Vibrio vulnificus cabABC genes which were preferentially
expressed in biofilms. The cabABC genes were transcribed as a single operon. The cabA …

Bacteria in a biofilm community have increased tolerance to antimicrobial therapy. To
characterize the role of biofilms in equine endometritis, six mares were inoculated with lux …

Secreted polysaccharides are important functional and structural components of bacterial
biofilms. The opportunistic pathogen Pseudomonas aeruginosa produces the cationic …

Abstract c-di-GMP is a major player in the switch between biofilm and motile lifestyles.
Several bacteria exhibit a large number of c-di-GMP metabolizing proteins, thus a fine …

Cyclic dinucleotides such as bis-(3′, 5′)-cyclic dimeric guanosine monophosphate (3′,
3′-c-di-GMP) represent an important class of second messengers in bacteria and are …

The opportunistic pathogen Pseudomonas aeruginosa is a significant cause of infection in
immunocompromised individuals, cystic fibrosis patients, and burn victims. To benefit its …