Increasing evidence suggests that the failure of clinical antidepressants may be related with
neuroinflammation. The NOD-, LRR-and pyrin domain-containing protein 3 (NLRP3) …

The nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3)
inflammasome is an important part of the natural immune system that plays an important role …

Statins are commonly prescribed medications widely investigated for their potential actions
on the brain and mental health. Pre-clinical and clinical evidence suggests that statins may …

Major depressive disorder is one of the most prevalent mental health disorders. Monoamine-
based antidepressants were the first drugs developed to treat major depressive disorder …

Depression, a major public health problem, imposes a significant economic burden on
society. Recent studies have gradually unveiled the important role of neuroinflammation in …

Depression holds the title of the largest contributor to worldwide disability, with the numbers
expected to continue growing. Currently, there are neither reliable biomarkers for the …

Background and aims: Saikosaponin d (SSd) has a steroidal structure and significant anti-
inflammatory effects. The purpose of this study was to explore the mechanism underlying …

Clinical studies suggest that women are more likely than men to relapse to alcohol drinking
in response to stress; however, the mechanisms underlying this sex difference are not well …

The majority of research on the long-term effects of spinal cord injury (SCI) has primarily
focused on neuropathic pain (NP), psychological issues, and sensorimotor impairments …

Pyroptosis is an inflammasome-induced lytic form of programmed cell death, and its main
effect involves the release of inflammatory mediators when a cell dies, resulting in an …