The Hippo pathway has emerged as a conserved signaling pathway that is essential for the
proper regulation of organ growth in Drosophila and vertebrates. Although the mechanisms …

The heart is the first organ formed during mammalian development. A properly sized and
functional heart is vital throughout the entire lifespan. Loss of cardiomyocytes because of …

Stem cell (SC) activity fluctuates throughout an organism's lifetime to maintain homeostatic
conditions in all tissues. As animals develop and age, their organs must remodel and …

Mps One Binder Kinase Activator (MOB) 1A/1B are core components of the Hippo pathway
that coactivate large tumor suppressor homolog (LATS) kinases. Mob1a/1b double …

Seed is one of the key factors of crop productivity. Therefore, a comprehension of the
mechanisms underlying seed formation in cultivated plants is crucial for the quantitative and …

Reactive oxygen species (ROS) are constantly produced in cells, an excess of which causes
oxidative stress. ROS has been linked to regulation of the Hippo pathway; however, the …

LATS2 kinase functions as part of the Hippo pathway to promote contact inhibition of growth
and tumor suppression by phosphorylating and inhibiting the transcriptional coactivator …

The angiosperm female gametophyte is critical for plant reproduction. It contains the egg cell
and central cell that become fertilized and give rise to the embryo and endosperm of the …

Mps one binder 1a (MOB1A) and MOB1B are key components of the Hippo signaling
pathway and are mutated or inactivated in many human cancers. Here we show that intact …

A cassette of cytoplasmic Drosophila tumor suppressors, including the kinases Hippo and
Warts, has recently been linked to the transmembrane tumor suppressor Fat. These proteins …