Brain iron homeostasis is maintained through the normal function of blood–brain barrier and
iron regulation at the systemic and cellular levels, which is fundamental to normal brain …

Background: Parkinson's disease (PD) is a neurodegenerative disorder characterized by
motor symptoms such as tremors, rigidity, and bradykinesia. Rehabilitation utilizing mirror …

Purpose Susceptibility map weighted imaging (SMWI), based on quantitative susceptibility
mapping (QSM), allows accurate nigrosome-1 (N1) evaluation and has been used to …

Background There is a lack of automated tools for the segmentation and quantification of
neuromelanin (NM) and iron in the nigrosome‐1 (N1). Existing tools evaluate the N1 sign, ie …

Background Differential diagnosis of essential tremor (ET) and Parkinson's disease (PD) can
still be a challenge in clinical practice. These two tremor disorders may have different …

Background Parkinson's disease (PD) is associated with the loss of neuromelanin (NM) and
increased iron in the substantia nigra (SN). Magnetization transfer contrast (MTC) is widely …

Background: Iron deposition plays a crucial role in the pathophysiology of Parkinson's
disease (PD), yet the distribution pattern of iron deposition in the subcortical nuclei has been …

Purpose: Susceptibility map weighted imaging (SMWI), based on quantitative susceptibility
mapping (QSM), allows accurate nigrosome-1 (N1) evaluation and has been used to …

Currently, there are no disease-modifying therapies to counter the progression of
neurodegenerative diseases that are associated with mitochondrial dysfunction in the early …

Degeneration in the substantia nigra (SN) pars compacta (SNc) underlies motor symptoms
in Parkinson's disease (PD). Currently, there are no neuroimaging biomarkers that are …