Colorectal cancer (CRC) is one of the most lethal and prevalent solid malignancies
worldwide. There is a great need of accelerating the development and diagnosis of CRC …

Hypoxia-induced alternative splicing is a potent driving force in tumour pathogenesis and
progression. In this review, we update currents concepts of hypoxia-induced alternative …

Gut microbes participate in pathogenesis by interacting with the host genome through
epigenetic mechanisms, such as long non-coding RNAs. However, the mechanisms by …

Simple Summary Alternative splicing is one of the most fabulous and important mechanism
in the cell. Alternative splicing is capable of generating many proteins from a single gene …

Cancer metastasis and drug resistance are two major obstacles in the treatment of cancer
and therefore, the leading cause of cancer-associated mortalities worldwide. Hence, an in …

The transcription factor nuclear factor erythroid 2-related factor 2 (NRF2) and its negative
regulator kelch-like ECH-associated protein 1 (KEAP1) regulate various genes involved in …

Aberrant splicing events are associated with colorectal cancer (CRC) and provide new
opportunities for tumor diagnosis and treatment. The expression of the splice variants of NF …

Alternative splicing (AS) is an important event that contributes to posttranscriptional gene
regulation. This process leads to several mature transcript variants with diverse …

Simple Summary Epigenetics studies the alteration of gene expression without changing
DNA sequence and very often, epigenetic dysregulation causes cancer. Alternative splicing …

At present, after extensive studies in the field of cancer, cancer stem cells (CSCs) have been
proposed as a major factor in tumor initiation, progression, metastasis, and recurrence …