Clostridium difficile is a major cause of intestinal infection and diarrhoea in individuals
following antibiotic treatment. Recent studies have begun to elucidate the mechanisms that …

Clostridioides difficile is a Gram-positive, spore-forming, toxin-producing anaerobe, and an
important nosocomial pathogen. Due to the strictly anaerobic nature of the vegetative form …

Large clostridial toxins (LCTs) are a family of bacterial exotoxins that infiltrate and destroy
target cells. Members of the LCT family include Clostridioides difficile toxins TcdA and TcdB …

The pathogenic clostridia cause many human and animal diseases, which typically arise as
a consequence of the production of potent exotoxins. Among the enterotoxic clostridia …

Strains of Clostridioides difficile cause detrimental diarrheas with thousands of deaths
worldwide. The infection process by the Gram-positive, strictly anaerobic gut bacterium is …

The catabolite control protein CcpA is a pleiotropic regulator that mediates the global
transcriptional response to rapidly catabolizable carbohydrates, like glucose in Gram …

As obligate anaerobes, clostridial pathogens depend on their metabolically dormant, oxygen-
tolerant spore form to transmit disease. However, the molecular mechanisms by which those …

Clostridium difficile is the largest single cause of hospital-acquired infection in the United
States. A major risk factor for Clostridium difficile infection (CDI) is prior exposure to …

Clostridioides difficile is an opportunistic diarrheal pathogen responsible for significant
morbidity and mortality worldwide. A disrupted (dysbiotic) gut microbiome, commonly …

Clostridium difficile, a proteolytic Gram-positive anaerobe, has emerged as a significant
nosocomial pathogen. Stickland fermentation reactions are thought to be important for …