Hypoxia-inducible factors (HIFs) are highly conserved transcription factors that are crucial for
adaptation of metazoans to limited oxygen availability. Recently, HIF activation and …

Hypoxia, characterized by reduced oxygen concentration, is a significant stressor that affects
the survival of aerobic species and plays a prominent role in cardiovascular diseases. From …

Clinical use of doxorubicin (DOX) is limited because of its cardiotoxicity, referred to as DOX-
induced cardiomyopathy (DIC). Mitochondria-dependent ferroptosis, which is triggered by …

Kynurenic acid (KynA) is tissue protective in cardiac, cerebral, renal, and retinal ischemia
models, but the mechanism is unknown. KynA can bind to multiple receptors, including the …

Summary Ischemia-reperfusion (I/R) injury is a promising therapeutic target to improve
clinical outcomes after acute myocardial infarction. Ferroptosis, triggered by iron overload …

Oxygen is essential for living organisms. Molecular oxygen binds to hemoglobin and is
delivered to every organ in the body. In several cardiovascular diseases or anemia, local …

Background: Ferroptosis has been found to play an important role in myocardial ischemia
reperfusion (MIR) injury (MIRI). This study aimed to explore whether the improvement effect …

Despite increasing availability and more successful interventional approaches to restore
coronary reperfusion, myocardial ischemia-reperfusion injury is a substantial cause of …

Hypoxia inducible factors (HIFs) and their regulatory hydroxylases the prolyl hydroxylase
domain enzymes (PHDs) are the key mediators of the cellular response to hypoxia. HIFs are …

Ischemia/reperfusion (I/R) injury is characterized by a limited blood supply to organs,
followed by the restoration of blood flow and reoxygenation. In addition to ischemia, blood …