Models of fetal brain injury, intrauterine inflammation, and preterm birth

I Burd, B Balakrishnan, S Kannan - American journal of …, 2012 - Wiley Online Library
Intrauterine infection and inflammation are known risk factors for brain damage in the
neonate irrespective of the gestational age. Infection‐induced maternal immune activation …

The role of environmental exposures as risk factors for bipolar disorder: a systematic review of longitudinal studies

C Marangoni, M Hernandez, GL Faedda - Journal of affective disorders, 2016 - Elsevier
Background The role of environmental risk factors in the development of bipolar disorder
(BD) is not well characterized. We evaluate the prevalence, duration, and predictive value of …

Intrauterine inflammation, insufficient to induce parturition, still evokes fetal and neonatal brain injury

MA Elovitz, AG Brown, K Breen, L Anton… - International Journal of …, 2011 - Elsevier
Exposure to prenatal inflammation is a known risk factor for long term neurobehavioral
disorders including cerebral palsy, schizophrenia, and autism. Models of systemic …

Weak functional connectivity in the human fetal brain prior to preterm birth

ME Thomason, D Scheinost, JH Manning, LE Grove… - Scientific reports, 2017 - nature.com
It has been suggested that neurological problems more frequent in those born preterm are
expressed prior to birth, but owing to technical limitations, this has been difficult to test in …

Infections and brain development

CN Cordeiro, M Tsimis, I Burd - Obstetrical & gynecological survey, 2015 - journals.lww.com
Several different bodies of evidence support a link between infection and altered brain
development. Maternal infections, such as influenza and human immunodeficiency virus …

Next generation strategies for preventing preterm birth

HC Zierden, RL Shapiro, K DeLong, DM Carter… - Advanced drug delivery …, 2021 - Elsevier
Preterm birth (PTB) is defined as delivery before 37 weeks of gestation. Globally, 15 million
infants are born prematurely, putting these children at an increased risk of mortality and …

The role of inflammation and infection in preterm birth

JA Bastek, LM Gómez… - Clinics in …, 2011 - perinatology.theclinics.com
Preterm birth is defined as delivery before 37 weeks' gestation. In 2010, the incidence of
preterm birth in the United States was 12.3% 1 and ranged from 8% to 12% in developed …

Inflammation‐induced preterm birth alters neuronal morphology in the mouse fetal brain

I Burd, AI Bentz, J Chai, J Gonzalez… - Journal of …, 2010 - Wiley Online Library
Adverse neurological outcome is a major cause of long‐term morbidity in ex‐preterm
children. To investigate the effect of parturition and inflammation on the fetal brain, we …

IL‐1 receptor blockade prevents fetal cortical brain injury but not preterm birth in a mouse model of inflammation‐induced preterm birth and perinatal brain injury

K Leitner, M Al Shammary, M McLane… - American journal of …, 2014 - Wiley Online Library
Problem Exposure to intrauterine inflammation, associated with preterm birth, has been
linked to a devastating spectrum of neurobehavioral disorders. Mechanisms of this injury are …

[HTML][HTML] Specific lipopolysaccharide serotypes induce differential maternal and neonatal inflammatory responses in a murine model of preterm labor

R Migale, BR Herbert, YS Lee, L Sykes… - The American journal of …, 2015 - Elsevier
Intrauterine inflammation is recognized as a key mediator of both normal and preterm birth
but is also associated with neonatal neurological injury. Lipopolysaccharide (LPS) is often …