Stem cells are defined by their capabilities to self-renew and give rise to various types of
differentiated cells depending on their potency. They are classified as pluripotent …

The induction of teratoma in mice by the transplantation of stem cells into extra-uterine sites
has been used as a read-out for cellular pluripotency since the initial description of this …

The transcription factor Nkx2. 5 and the intermediate filament protein desmin are
simultaneously expressed in cardiac progenitor cells during commitment of primitive …

Because of the minimal and clearly insufficient ability of the adult heart to regenerate after
ischemic injury, there is a great opportunity to identify biological mechanisms, substances …

In the past, the heart muscle was thought to originate from a single source of myocardial
progenitor cells. More recently, however, an additional source of myocardial progenitors has …

The general idea of regenerative medicine is to fix or replace tissues or organs with live and
patient-specific implants. Pluripotent stem cells are capable of indefinite self-renewal and …

BACKGROUND: The mammalian heart contains cardiac stem cells throughout life, but it has
not been possible to harness or stimulate these cells to repair damaged myocardium in vivo …

Intra-cardiac cell transplantation is a new therapy after myocardial infarction. Its success,
however, is impeded by the limited capacity of donor cells to differentiate into functional …

Background/Aims: Cell transplantation into the heart is a new therapy after myocardial
infarction. Its success, however, is impeded by poor donor cell survival and by limited …

By 2030 more than 23 million people will die annually from cardiovascular diseases (CVDs).
CVDs are the number one cause of death globally, which equates 30% of all global deaths …