Lysosomes are cytoplasmic organelles that contain a variety of different hydrolases. A
genetic deficiency in the enzymatic activity of one of these hydrolases will lead to the …

Current therapeutic interventions for neurodegenerative diseases alleviate only disease
symptoms, while treatments that could stop or reverse actual degenerative processes are …

The understanding of the epidemiology of diabetic peripheral neuropathy has been made
difficult by methodological issues relating to many of the published studies. Inconsistency in …

GPR37 (also known as Pael-R) and GPR37L1 are orphan G protein-coupled receptors that
are almost exclusively expressed in the nervous system. We screened these receptors for …

NK-lysin is the first representative of a family of sequence related proteins--saposins,
surfactant-associated protein B, pore forming amoeba proteins, and domains of acid …

Astrocytes are key homeostatic cells of the central nervous system. They cooperate with
neurons at several levels, including ion and water homeostasis, chemical signal …

Prosaposin (also known as SGP-1) is an intriguing multifunctional protein that plays roles
both intracellularly, as a regulator of lysosomal enzyme function, and extracellularly, as a …

The four established or putative sphingolipid activator proteins derive from a large precursor
protein encoded by a single gene. In addition to generating the four sphingolipid activator …

Abstract Progranulin (GRN) loss-of-function mutations leading to progranulin protein
(PGRN) haploinsufficiency are prevalent genetic causes of frontotemporal dementia …

The molecular, genetic and enzymological abnormalities in Gaucher's disease have been
delineated during the past decade. Although our understanding of the primary …